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Gelatin (from porcine skin)

Cat. No. M10368
Gelatin (from porcine skin) Structure
Size Price Availability Quantity
100g USD 55  USD55 In stock
500g USD 110  USD110 In stock
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Quality Control & Documentation
  • Purity: Pharmaceutical grade, gel strength >180 g Bloom
  • COA
  • MSDS
Biological Activity

Gelatin is a heterogeneous mixture of water-soluble proteins of high average molecular masses, present in collagen. Gelatin has been used in many applications. It has use in coating cell culture to improve attachment of cells, being added to PCR to stabilize Taq DNA, as a blocking reagent in Western blotting, ELISA, and immunochemistry, and as a component of media for species differentiation in bacteriology. As a biocompatible polymer, it has used as a delivery vehicle for release of active biomolecules and in generation of scaffolds for tissue engineering applications. In the pharmaceutical industry, geltan can be used as a suspending and encapsulating agent, among other applications. Gelatin is soluble in hot than in cold water. It is practically insoluble in most organic solvents such as alcohol, chloroform, carbon disulfide, carbon tetrachloride, ether, benzene, acetone, and oils.

Product Citations
Chemical Information
CAS Number 9000-70-8
Solubility (25°C) Water 67 mg/mL at 50 °C
Storage RT, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bin Liu, et al. Mater Sci Eng C Mater Biol Appl. 3D-bioprinted functional and biomimetic hydrogel scaffolds incorporated with nanosilicates to promote bone healing in rat calvarial defect model

[2] Panuphong Pootawang, et al. J Nanosci Nanotechnol. Incorporation of Ag metallic nanoparticles in 3D gelatin matrix via the green strategy solution plasma

[3] Leslie Crews, et al. J Neurosci. Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice

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