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Cat. No. M2561
NMS-873 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
2mg USD 35  USD35 In stock
5mg USD 67  USD67 In stock
10mg USD 125  USD125 In stock
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Quality Control & Documentation
Biological Activity

NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM. NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC50 values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC50 values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain.

Product Citations
Customer Product Validations & Biological Datas
Source Nature (2017). Figure 6. NMS873 (Abmole Bioscience)
Method Western blot
Cell Lines NIH3T3 cells
Concentrations 5 μM
Incubation Time 3 h
Results In contrast to treatment with NMS873, CuET had no effect on p97 ATPase activity
Source Nature (2017). Figure 4. NMS873 (Abmole Bioscience)
Method Western blot
Cell Lines NIH3T3 cells
Concentrations 5 μM
Incubation Time 3 h
Results We confirmed UPR in cells treated with CuET or NMS873 by detecting increased markers of UPR induction, including the spliced form of XBP1s, ATF4 and phosphorylated (p-) eIF2α33
Source Nature (2017). Figure 2. NMS873 (Abmole Bioscience)
Method colony-formation assay
Cell Lines U2OS cell
Concentrations 10 μM
Incubation Time 16 h
Results Furthermore, consistent with cleavage of the 120-kDa species of the endoplasmic reticulum-tethered transcription factor NRF1 into an active 110-kDa form being a p97-dependent process30, appearance of the cleaved NRF1 form was inhibited by both CuET and NMS873
Chemical Information
Molecular Weight 520.67
Formula C27H28N4O3S2
CAS Number 1418013-75-8
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Gang Zhang, et al. A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells

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Abmole Inhibitor Catalog

Keywords: NMS-873 supplier, p97, inhibitors, activators

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