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TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor with an IC50 of 2.7 nM. In primary mouse neuronal cultures at DIV14, and analysis of neurite branching is used as a surrogate of neuron health. At chronic effects test, TTBK1-IN-1 (0.0625-100 μM; 6-24 hours) cause a significant decrease in neurite length at the 50 and 100 μM concentrations beginning at 12-18 h following treatment.
| Molecular Weight | 337.38 |
| Formula | C18H19N5O2 |
| CAS Number | 2735015-60-6 |
| Form | Solid |
| Solubility (25°C) | Ethanol 30 mg/mL |
| Storage | 4°C, dry, sealed |
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