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Recombinant Human/Mouse/Rat BMP-2 (E.coli)

Cat. No. M11494
Recombinant Human/Mouse/Rat BMP-2 (E.coli) Structure
Synonym:

Bone Morphogenetic Protein 2; BMP-2

Size Price Availability Quantity
10ug USD 208  USD208 In stock
50ug USD 600  USD600 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 0.01 EU/μ
  • COA
  • MSDS
Biological Activity

Expression system: E. coli
Purity: > 95% as determined by reduced SDS-PAGE.
Endotoxin: LAL test: less than 0.001 ng/μg (0.01 EU/μg)
Storage and stability: Lyophilized proteins should be stored at < -20°C but can be stored at room temperature for up to 3 weeks. The recombinant protein solution can be stored at 4-7℃ for 2-7 days. The isometric solution of the recombinant sample was stable at < -20°C for 3 months.


Biological activity: Bone Morphogenetic protein-2 (BMP-2) is a Bone growth regulator, belonging to transforming growth factor - β (TGF - β) superfamily Protein. BMP is synthesized from macromolecular precursors cleaved by proteolytic enzymes. The active form of BMP-2 may consist of dimers of two identical proteins or heterodimers of two related bone morphogenetic proteins.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 0.01 EU/μ
Solubility It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Storage at -20°C
References

[1] Szu-Yu Chien, et al. Cells. Noggin Inhibits IL-1β and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis

[2] Xiao Zhang, et al. Growth Factors. Heterodimeric BMP-2/7 exhibits different osteoinductive effects in human and murine cells

[3] Nina Bono, et al. J Appl Biomater Funct Mater. BMP-2 and type I collagen preservation in human deciduous teeth after demineralization

[4] Branko Skovrlj, et al. Spine (Phila Pa 1976). Association Between BMP-2 and Carcinogenicity

[5] Shijun Wei, et al. Orthopedics. Recombinant human BMP-2 for the treatment of open tibial fractures

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Keywords: Recombinant Human/Mouse/Rat BMP-2 (E.coli), Bone Morphogenetic Protein 2; BMP-2 supplier, Cytokines, inhibitors

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