All AbMole products are for research use only, cannot be used for human consumption.
Recombinant Human Bone Morphogenetic Protein-2 (BMP-2) is a bone-growth regulatory factor and belongs to the transforming growth factor-beta (TGF-beta) superfamily. Human Bone Morphogenetic Protein-2 (BMP-2) is synthesized as large precursor molecule (Met1-Arg396, with a signal peptide from Met1 to Gly23), propeptide (Leu24-Arg282) of which is cleaved by PCSK5 (Proprotein Convertase Subtilisin/Kexin type 5). BMP-2 plays an important role in the development of bone and cartilage, cardiac cell differentiation and epithelial to mesenchymal transition. It is also involved in the hedgehog pathway, TGF-beta signaling pathway, and in cytokine-cytokine receptor interaction.
Measured by its ability to induce alkaline phosphatase production by ATDC-5 Cells, the ED50 for this effect is typically 0.07-0.2 µg/ml.
Measured by its ability to induce alkaline phosphatase production by C2C12 cells, the ED50 for this effect is typically 0.2-1 µg/ml.
Accession: # P12643
Apparent Molecular Weight: ~26 kDa, on SDS-PAGE under non-reducing conditions.
Lyophilized after extensive dialysis against 50 mM acetic acid.
| Solubility (25°C) | Reconstitute the lyophilized powder in 20 mM AcOH or 5 mM HCl up to 100 μg/ml. |
| Storage | Stable for up to 6 months at lower than -70°C |
[4] Branko Skovrlj, et al. Spine (Phila Pa 1976). Association Between BMP-2 and Carcinogenicity
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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