All AbMole products are for research use only, cannot be used for human consumption.
Acetylcysteine(NAC; N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.
Cell Metab. 2024 Jan;S1550-4131(23)00477-1.
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment
Acetylcysteine (NAC) purchased from AbMole
Int J Oral Sci. 2024 May 22;16(1):41.
Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure
Acetylcysteine (NAC) purchased from AbMole
Biomed Pharmacother. 2024 Feb 23;173:116304..
Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis
Acetylcysteine (NAC) purchased from AbMole
Inflamm. Res. 2024 Feb;73, 175-181.
The immunomodulatory efects of metformin in LPS‑induced macrophages: an in vitro study
Acetylcysteine (NAC) purchased from AbMole
ACS Biomater Sci Eng. 2024 May 13;10(5):2995-3005.
Ca2+ Overload Decreased Cellular Viability in Magnetic Hyperthermia without a Macroscopic Temperature Rise
Acetylcysteine (NAC) purchased from AbMole
J Sci Food Agric. 2024 Jun 3.
N-Acetylcysteine assists muscle development in offspring of mice subjected to maternal heat stress during pregnancy
Acetylcysteine (NAC) purchased from AbMole
Asian Journal of Pharmaceutical Sciences. 2023 Nov.
Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma
Acetylcysteine (NAC) purchased from AbMole
Sci Total Environ. 2023 Dec;30:913:169730.
Selenium deficiency exacerbated Bisphenol A-induced intestinal toxicity in chickens: Apoptosis and cell cycle arrest mediated by ROS/P53
Acetylcysteine (NAC) purchased from AbMole
Front Immunol. 2023 Mar 14;14:1120996.
ROS-AMPK/mTOR-dependent enterocyte autophagy is involved in the regulation of Giardia infection-related tight junction protein and nitric oxide levels
Acetylcysteine (NAC) purchased from AbMole
Int J Biol Macromol. 2023 Dec 31;253(Pt 8):127501.
Bisphenol A exposure exacerbates tracheal inflammatory injury in selenium-deficient chickens by regulating the miR-155/TRAF3/ROS pathway
Acetylcysteine (NAC) purchased from AbMole
Free Radic Biol Med. 2023 Mar 27;202:46-61.
Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)–NF–кB axis
Acetylcysteine (NAC) purchased from AbMole
J Cell Physiol. 2023 Apr 3.
Bisphenol A aggravate selenium deficiency‐induced apoptosis via miR‐215‐3p/Dio1 to activate ROS/PI3K/AKT pathway in chicken arterial
Acetylcysteine (NAC) purchased from AbMole
J Cell Physiol. 2023 Jun 3.
miR-210/NF-κB axis: A new direction for regulating cadmium-induced pig artery inflammatory injury
Acetylcysteine (NAC) purchased from AbMole
J Photochem Photobiol B. 2023 Jun 5;245:112735.
The AMPK-dependent inhibition of autophagy plays a crucial role in protecting photoreceptor from photooxidative injury
Acetylcysteine (NAC) purchased from AbMole
Chin J Nat Med. 2023 Sep 6;21(10): 759-774.
Paeonol reduces microbial metabolite α-hydroxyisobutyric acid to alleviate the ROS/TXNIP/NLRP3 pathway-mediated endothelial inflammation in atherosclerosis mice
Acetylcysteine (NAC) purchased from AbMole
Acta Pharm Sin B. 2022 May;12(5):2300-2314.
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1
Acetylcysteine (NAC) purchased from AbMole
J Hazard Mater. 2022 Oct 5;439:129502.
Polystyrene nanoparticle exposure supports ROS-NLRP3 axis-dependent DNA-NET to promote liver inflammation
Acetylcysteine (NAC) purchased from AbMole
J Pharm Anal. 2022 Aug;12(4):570-582.
18beta-Glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs
Acetylcysteine (NAC) purchased from AbMole
Neurochem Res. 2022 Oct 30.
MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line
Acetylcysteine (NAC) purchased from AbMole
Environ Toxicol. 2022 Oct;37(10):2552-2565.
Polystyrene nanoplastics exacerbated lipopolysaccharide‐induced necroptosis and inflammation via the ROS/MAPK pathway in mice spleen
Acetylcysteine (NAC) purchased from AbMole
Redox Biol. 2021 Aug;44:102003.
Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis
Acetylcysteine (NAC) purchased from AbMole
Acta Pharm Sin B. 2021 Nov 10.
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1
Acetylcysteine (NAC) purchased from AbMole
Ecotoxicol Environ Saf. 2021 Oct 1;222:112488.
H2S exposure induces cell death in the broiler thymus via the ROS-initiated JNK/MST1/FOXO1 pathway
Acetylcysteine (NAC) purchased from AbMole
Front Oncol. 2021 May 26;11:679816.
Antidiabetic Agent DPP-4i Facilitates Murine Breast Cancer Metastasis by Oncogenic ROS-NRF2-HO-1 Axis via a Positive NRF2-HO-1 Feedback Loop
Acetylcysteine (NAC) purchased from AbMole
Front Oncol. 2021 Sep 24;11:728047.
Antidiabetic DPP-4 Inhibitors Reprogram Tumor Microenvironment That Facilitates Murine Breast Cancer Metastasis Through Interaction With Cancer Cells via a ROS–NF-кB–NLRP3 Axis
Acetylcysteine (NAC) purchased from AbMole
J Infect Dis. 2021 Oct 28;224(8):1333-1344.
Distinct Mitochondria-Mediated T-Cell Apoptosis Responses in Children and Adults With Coronavirus Disease 2019
Acetylcysteine (NAC) purchased from AbMole
Pathogens. 2020 Aug 23;9(9):693.
Giardia duodenalis Induces Apoptosis in Intestinal Epithelial Cells via Reactive Oxygen Species-Mediated Mitochondrial Pathway In Vitro
Acetylcysteine (NAC) purchased from AbMole
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Source | Pathogens 2020 Aug. Figure 5. N-acetyl-l-cysteine (Abmole Bioscience Inc, Houston, TX, USA) |
| Method | Cell Viability Assay | |
| Cell Lines | Caco-2 cells | |
| Concentrations | 10 mM/well | |
| Incubation Time | 6 h | |
| Results | It was shown in Figure 5A that pre-incubation of Caco-2 cells with NAC for 3 h before exposure to trophozoites could block the release of Cyt-c. The activation of CASP3 was diminished by NAC in trophozoites-treated cells |
| Molecular Weight | 163.19 |
| Formula | C5H9NO3S |
| CAS Number | 616-91-1 |
| Solubility (25°C) | DMSO 30 mg/mL Water 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ROS Products |
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| Dihydroferulic acid
Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid (Hydroferulic acid) is a metabolite of human gut microflora as well as a precursor of vanillic acid. |
| Arg-Tyr
Arg-Tyr is a dipeptide which has strong hydroxyl-radical and hydrogen-peroxide scavenging activity. |
| HNGF6A
HNGF6A is a humanin analogue. |
| Glutathione ethyl ester
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. |
| Palmitoyl tripeptide-38
Palmitoyl tripeptide-38 is a bioactive peptide with anti-aging effect . |
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Products are for research use only. Not for human use. We do not sell to patients.
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