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Acetylcysteine (NAC)

Cat. No. M5385
Acetylcysteine (NAC) Structure

N-Acetyl-L-cysteine; NAC; N-acetylcysteine; N-Acetyl-Cysteine

Size Price Availability Quantity
Free Sample (1-2 mg)  USD 0 In stock
500mg USD 30  USD30 In stock
1g USD 40  USD40 In stock
5g USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Acetylcysteine(NAC; N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.

Product Citations
Customer Product Validations & Biological Datas
Source Pathogens 2020 Aug. Figure 5. N-acetyl-l-cysteine (Abmole Bioscience Inc, Houston, TX, USA)
Method Cell Viability Assay
Cell Lines Caco-2 cells
Concentrations 10 mM/well
Incubation Time 6 h
Results It was shown in Figure 5A that pre-incubation of Caco-2 cells with NAC for 3 h before exposure to trophozoites could block the release of Cyt-c. The activation of CASP3 was diminished by NAC in trophozoites-treated cells
Chemical Information
Molecular Weight 163.19
Formula C5H9NO3S
CAS Number 616-91-1
Solubility (25°C) DMSO 30 mg/mL
Water 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Qiuting Zhang, et al. J Cancer. Artemisinin Derivatives Inhibit Non-small Cell Lung Cancer Cells Through Induction of ROS-dependent Apoptosis/Ferroptosis

[2] Stutzman D, et al. Am J Health Syst Pharm. Acetylcysteine for treatment of autism spectrum disorder symptoms.

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Keywords: Acetylcysteine (NAC), N-Acetyl-L-cysteine; NAC; N-acetylcysteine; N-Acetyl-Cysteine supplier, ROS, inhibitors, activators

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