Acetylcysteine(NAC; N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.
Chin J Nat Med. 2023 Sep 6;21(10): 759-774.
Paeonol reduces microbial metabolite α-hydroxyisobutyric acid to alleviate the ROS/TXNIP/NLRP3 pathway-mediated endothelial inflammation in atherosclerosis mice
Acetylcysteine (NAC) purchased from AbMole
J Photochem Photobiol B. 2023 Jun 5;245:112735.
The AMPK-dependent inhibition of autophagy plays a crucial role in protecting photoreceptor from photooxidative injury
Acetylcysteine (NAC) purchased from AbMole
J Cell Physiol. 2023 Jun 3.
miR-210/NF-κB axis: A new direction for regulating cadmium-induced pig artery inflammatory injury
Acetylcysteine (NAC) purchased from AbMole
Front Immunol. 2023 Mar 14;14:1120996.
ROS-AMPK/mTOR-dependent enterocyte autophagy is involved in the regulation of Giardia infection-related tight junction protein and nitric oxide levels
Acetylcysteine (NAC) purchased from AbMole
J Cell Physiol. 2023 Apr 3.
Bisphenol A aggravate selenium deficiency‐induced apoptosis via miR‐215‐3p/Dio1 to activate ROS/PI3K/AKT pathway in chicken arterial
Acetylcysteine (NAC) purchased from AbMole
Free Radic Biol Med. 2023 Mar 27;202:46-61.
Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)–NF–кB axis
Acetylcysteine (NAC) purchased from AbMole
Environ Toxicol. 2022 Oct;37(10):2552-2565.
Polystyrene nanoplastics exacerbated lipopolysaccharide‐induced necroptosis and inflammation via the ROS/MAPK pathway in mice spleen
Acetylcysteine (NAC) purchased from AbMole
Neurochem Res. 2022 Oct 30.
MiR-29c Inhibits TNF-α-Induced ROS Production and Apoptosis in Mouse Hippocampal HT22 Cell Line
Acetylcysteine (NAC) purchased from AbMole
J Pharm Anal. 2022 Aug;12(4):570-582.
18beta-Glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs
Acetylcysteine (NAC) purchased from AbMole
J Hazard Mater. 2022 Oct 5;439:129502.
Polystyrene nanoparticle exposure supports ROS-NLRP3 axis-dependent DNA-NET to promote liver inflammation
Acetylcysteine (NAC) purchased from AbMole
Acta Pharm Sin B. 2022 May;12(5):2300-2314.
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1
Acetylcysteine (NAC) purchased from AbMole
Acta Pharm Sin B. 2021 Nov 10.
Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1
Acetylcysteine (NAC) purchased from AbMole
Ecotoxicol Environ Saf. 2021 Oct 1;222:112488.
H2S exposure induces cell death in the broiler thymus via the ROS-initiated JNK/MST1/FOXO1 pathway
Acetylcysteine (NAC) purchased from AbMole
J Infect Dis. 2021 Oct 28;224(8):1333-1344.
Distinct Mitochondria-Mediated T-Cell Apoptosis Responses in Children and Adults With Coronavirus Disease 2019
Acetylcysteine (NAC) purchased from AbMole
Front Oncol. 2021 Sep 24;11:728047.
Antidiabetic DPP-4 Inhibitors Reprogram Tumor Microenvironment That Facilitates Murine Breast Cancer Metastasis Through Interaction With Cancer Cells via a ROS–NF-кB–NLRP3 Axis
Acetylcysteine (NAC) purchased from AbMole
Front Oncol. 2021 May 26;11:679816.
Antidiabetic Agent DPP-4i Facilitates Murine Breast Cancer Metastasis by Oncogenic ROS-NRF2-HO-1 Axis via a Positive NRF2-HO-1 Feedback Loop
Acetylcysteine (NAC) purchased from AbMole
Ecotoxicol Environ Saf. 2021 Oct 1;222:112488.
H 2 S exposure induces cell death in the broiler thymus via the ROS-initiated JNK/MST1/FOXO1 pathway
Acetylcysteine (NAC) purchased from AbMole
Redox Biol. 2021 Aug;44:102003.
Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis
Acetylcysteine (NAC) purchased from AbMole
Pathogens. 2020 Aug 23;9(9):693.
Giardia duodenalis Induces Apoptosis in Intestinal Epithelial Cells via Reactive Oxygen Species-Mediated Mitochondrial Pathway In Vitro
Acetylcysteine (NAC) purchased from AbMole
Molecular Weight | 163.19 |
Formula | C5H9NO3S |
CAS Number | 616-91-1 |
Solubility (25°C) | DMSO 30 mg/mL Water 30 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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Pelargonidin-3,5-O-diglucoside chloride
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