About 30 results found for searched term "ROS" (0.043 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1894 | Rosiglitazone | PPAR |
| BRL 49653 | ||
| Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50=60 nM, Kd=40 nM). Rosiglitazone is an TRPC5 activator (EC50=30 μM) and TRPM3 inhibitor. | ||
| M1974 | Roscovitine | CDK |
| Seliciclib; CYC202; (R)-Roscovitine | ||
| Roscovitine (Seliciclib) is a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5, with IC50 values of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively. | ||
| M2038 | Rosiglitazone maleate | PPAR |
| Avandia | ||
| Rosiglitazone maleate (Avandia) is a potent and selective PPARγ ligand that binds to the PPARγ ligand-binding domain with a Kd value of 43 nM. | ||
| M2066 | Staurosporine | PKC |
| AM-2282; STS | ||
| Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. | ||
| M2283 | Rosuvastatin calcium | HMG-CoA Reductase |
| Crestor; ZD 4522 Calcium | ||
| Rosuvastatin (Crestor) is a member of statins and used to treat high cholesterol and related conditions. | ||
| M2315 | Necrostatin-1 | RIPK |
| Nec-1 | ||
| Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO. | ||
| M2670 | Epiandrosterone | Androgen Receptor |
| 3β-androsterone, EpiA | ||
| Epiandrosterone is a steroid hormone with weak androgenic activity, is a natural metabolite of DHEA. | ||
| M2674 | Eprosartan Mesylate | Angiotensin Receptor |
| Futuran; Navixen | ||
| Eprosartan is a nonpeptide angiotensin II receptor antagonist, [3H]-eprosartan binds to the AT1 receptor with KD of 0.83 nM in rat vascular smooth muscle cells. | ||
| M2698 | Ferrostatin-1 | Ferroptosis |
| Fer-1 | ||
| Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. | ||
| M3035 | Sucralose | Metabolite/Endogenous Metabolite |
| E955; Trichlorosucrose | ||
| Sucralose is an artificial and noncaloric sweetener, not broken down by the body. | ||
| M59307 | α-Methyl-p-tyrosine | Tyrosinase |
| AMPT; DL-alpha-Methyltyrosine; α-Methyl-D,L-tyrosine | ||
| α-Methyl-p-tyrosine (AMPT) is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. | ||
| M3331 | Trospium chloride | AChR/AChE |
| Trospium chloride is an orally active, competitive muscarinic cholinergic receptors (mAChRs) antagonist. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors. | ||
| M3409 | Formestane | Others |
| 4-hydroxyandrostenedione | ||
| Formestane is a second generation selective aromatase inhibitor with an IC50 of 80 nM. | ||
| M3436 | Furosemide | Sodium Channel |
| Furosemide is a tabular diuretic used in studies of congestive heart failure and edema. | ||
| M3459 | Lubiprostone | Others |
| CAS# 333963-40-9 | ||
| Lubiprostone is a gastrointestinal agent used for the treatment of idiopathic chronic constipation. | ||
| M3696 | Rostafuroxin | ATPase |
| PST 2238 | ||
| Rostafuroxin, a novel antihypertensive compound, acts as a selective inhibitor of srC-SH2 interaction with Na, K-ATPase activated by mutated adducin and Wabin in vivo. | ||
| M59271 | Atrosab | TNF Receptor |
| Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated Apoptosis induction and IL-6 and IL-8 production. Atrosab reduces neurological deficits. | ||
| M3881 | Tafluprost | Prostaglandin Receptor |
| Taflotan, Zioptan, AFP-168, MK2452 | ||
| Tafluprost is a fluorinated analog of prostaglandin F2-alpha and a PGF2alpha agonist that may be used in glaucoma-related studies. | ||
| M3899 | Salidroside | mTOR |
| Rhodioloside | ||
| Salidroside is a phenylpropanoid extracted from Rhodiola rosea that exhibits a protective effect against iron death by activating AMPK. It is also a prolyl endopeptidase inhibitor. | ||
| M3910 | Sweroside | Others |
| Sweroside is a bioactive herbal ingredient isolated from Fructus Corni, which has been widely used for the treatment of osteoporosis in traditional Chinese medicine (TCM). | ||
| M3926 | Cynaroside | Akt |
| Luteolin-7-O-D-glucopyranoside | ||
| Cynaroside is a flavone, it is a 7-O-glucoside of luteolin that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. | ||
| M4004 | Hyperoside | Apoptosis |
| Quercetin 3-O-galactoside; Quercetin 3-O-β-D-galactopyranoside | ||
| Hyperoside is a potent natural activator of Nur77 receptor, which can be potentially used for the research of occlusive vascular diseases. Hyperoside is also a NF-κB inhibitor. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis. | ||
| M4050 | Mogroside-V | ROS |
| Mogroside V is a triterpenoid glycoside, which is a non-saccharide sweetener. Mogroside V is nearly 300 times sweeter than sucrose. Mogrosides has antioxidant, anti-diabetic and anti-cancer activities. | ||
| M4051 | Mogroside-IVa | Others |
| Mogroside IV-A is A triterpenoid glycoside that can be isolated from the extract of momordica grosvenorii fruit. Mogroside IV-A is A non-carbohydrate sweetener. Mogroside is sweeter than sucrose. Mogroside has antioxidant, anti-diabetic and anticancer activities. | ||
| M4052 | Isomogroside-V | Others |
| Isomogroside V is a new sweetener extracted from momordica grosvenori fruit. | ||
| M4053 | Mogroside-IIIA1 | Others |
| Mogroside III-A1 is a triterpenoid glycoside, which is a non-saccharide sweetener. Mogroside is sweeter than sucrose. Mogroside has antioxidant, anti-diabetic and anticancer activities. | ||
| M4054 | Mogroside-IIA2 | Others |
| Mogroside II-A2 is a triterpenoid glycoside, which is a non-saccharide sweetener. Mogroside is sweeter than sucrose. Mogroside has antioxidant, anti-diabetic and anticancer activities. | ||
| M4055 | Mogroside-IIIe | Others |
| Mogroside III-E is a cucurbitane type compound isolated from momordica grosveneri, which can inhibit the release of NO and has anti-pulmonary fibrosis effect. | ||
| M4056 | Grosvenorine | Antibiotic |
| Grosvenorine is the main flavonoid in momordica Grosvenorine. Grosvenorine has good antibacterial and antioxidant activity. | ||
| M4057 | Mogroside-IV | Others |
| Mogroside IV is a triterpenoid glycoside that can be isolated from momordica fruit extract. Mogroside IV is a non-carbohydrate sweetener. Mogroside is sweeter than sucrose. Mogroside has antioxidant, anti-diabetic and anticancer activities. | ||
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