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Furosemide is a loop diuretic used in the treatment of congestive heart failure and edema. Furosemide acts by inhibiting the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the corticomedullary osmotic gradient and blocks negative as well as positive free water clearance.
| Molecular Weight | 330.74 |
| Formula | C12H11ClN2O5S |
| CAS Number | 54-31-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | 2-8°C, protect from light |
[3] No authors listed. IARC Monogr Eval Carcinog Risks Hum. Furosemide (frusemide)
[4] L L Ponto, et al. Furosemide (frusemide). A pharmacokinetic/pharmacodynamic review (Part I)
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