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Sodium Channel Sodium Channel

Cat.No.  Name Information
M3386 Amiloride hydrochloride Amiloride hydrochloride, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.
M3366 Amiloride hydrochloride dihydrate Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker.
M40701 Suzetrigine Suzetrigine (VX-548) is an orally active, highly selective NaV1.8 inhibitor , which can be used in studies related to acute pain and neuralgia.
M29408 AZ194  AZ194 is a first-in-class, orally active inhibitor of CRMP2-Ubc9 interaction and inhibitor of NaV1.7 (IC50=1.2 μM). AZ194 blocks SUMOylation of CRMP2 to selectively reduce the amount of surface-expressed NaV1.7. Antinociceptive effects.
M20814 VX-150 VX-150 (EOS-62073) is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold).
M14274 Riluzole hydrochloride Riluzole hydrochloride is an anticonvulsant drug and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
M14239 Istaroxime hydrochloride Istaroxime hydrochloride is a Na+/K+-ATPase inhibitor (IC50=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
M14238 Digitoxin Digitoxin is an effective Na+/K+-ATPase inhibitor, the EC50 value of Digitoxin is 0.78 μM.
M10868 Odevixibat Odevixibat (A4250) is a potent selective ileal bile acid transporter (IBAT) inhibitor. Odevixibat (A4250) mitigates cholestatic liver and bile duct damage in mouse models. Odevixibat (A4250) can be used in the study of primary biliary cirrhosis.
M10567 Acevaltrate Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively.
M10470 Raxatrigine hydrochloride Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a selective, small-molecule, state-dependent Nav1.7 voltage-gated sodium channel blocker.
M10458 Huwentoxin IV TFA Huwentoxin IV TFA is a selective NaV1.7 channel blocker, which preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM).
M10322 GSK-2330672 (Linerixibat) GSK-2330672, also known as linerixibat, is a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor for the research of type 2 diabetes.
M10113 BI01383298 BI01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
M9129 GNE-131 GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.
M9115 PF-06869206 PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM.
M9103 Eleclazine hydrochloride Eleclazine HCl is a novel late Na+ current inhibitor, with IC50 value of 0.7 uM.
M8988 PF-05089771 PF-05089771 is a selective Nav1.7 channel blocker that interacts with the voltage-sensor domain (VSD) of domain IV.
M8947 PF-01247324 PF-01247324 is a novel selective and orally bioavailable Nav 1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel.
M8911 GS967 GS967, also known as GS-458967, is a potent and selective blocker of cardiac late sodium current (late INa) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively.

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