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Sodium Channel Sodium Channel

Inhibitors

Cat.No.  Name Information
M21271 DS-1971a DS-1971a is a potent, homozygous form-selective aryl sulfonamide NaV1.7 inhibitor for the treatment of neuropathic pain.
M21188 NBI-921352 Zandatrigine (NBI-921352) is a sodium channel protein type 8 subunit alpha blocker.
M21126 GDC-0310 GDC-0310 is a selective Nav1.7 acyl sulfonamide inhibitor with an IC50 value of 0.6 nM for hNav1.7. It is an oral primary clinical candidate for the study of pain.
M21082 ABBV-318 ABBV-318 is a CNS-penetrating oral inhibitor of Nav1.7/Nav1.8 with IC50 values of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively, and is being developed for pain studies.
M20968 Benzonatate Benzonatate (Benzononatine) is a peripheral oral antitussive that dampens the activity of cough stretch receptors. Benzonatate has sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite.
M20923 Mepivacaine Mepivacaine is a tertiary amine used as a local anesthetic.
M20814 VX-150 VX-150 (EOS-62073) is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold).
M20507 (-)-Sparteine Sulfate Sparteine Sulfate, a quinolizidine alkaloid, is the sulfate form of sparteini, which is a sodium channel blocker used as an oxytocic and an anti-arrhythmia agent.
M15108 FR183998 free base FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.
M14275 Ropivacaine hydrochloride Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese.
M14274 Riluzole hydrochloride Riluzole hydrochloride is an anticonvulsant drug and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
M14273 Ralfinamide Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain.
M14272 Propoxycaine hydrochloride Propoxycaine hydrochloride inhibits voltage-gated sodium channels, and thereby inhibits the ionic flux required for the initiation and conduction of impulses. Propoxycaine hydrochloride application can lead to a loss of sensation.
M14271 Eniporide hydrochloride Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na+/H+ exchange inhibitor.
M14270 Disopyramide Disopyramide (Dicorantil) is a class IA antiarrhythmic drug with efficacy in ventricular and atrial arrhythmias.
M10492 Ropivacaine Ropivacaine is a member of the amino amide class of local anesthetics and acts as a potent sodium channel blocker.
M10470 Raxatrigine hydrochloride Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a selective, small-molecule, state-dependent Nav1.7 voltage-gated sodium channel blocker.
M10458 Huwentoxin IV TFA Huwentoxin IV TFA is a selective NaV1.7 channel blocker, which preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM).
M10113 BI01383298 BI01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
M9129 GNE-131 GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.



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