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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M21271 | DS-1971a | DS-1971a is a potent, homozygous form-selective aryl sulfonamide NaV1.7 inhibitor for the treatment of neuropathic pain. |
| M21188 | NBI-921352 | Zandatrigine (NBI-921352) is a sodium channel protein type 8 subunit alpha blocker. |
| M21126 | GDC-0310 | GDC-0310 is a selective Nav1.7 acyl sulfonamide inhibitor with an IC50 value of 0.6 nM for hNav1.7. It is an oral primary clinical candidate for the study of pain. |
| M21082 | ABBV-318 | ABBV-318 is a CNS-penetrating oral inhibitor of Nav1.7/Nav1.8 with IC50 values of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively, and is being developed for pain studies. |
| M20968 | Benzonatate | Benzonatate (Benzononatine) is a peripheral oral antitussive that dampens the activity of cough stretch receptors. Benzonatate has sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite. |
| M20923 | Mepivacaine | Mepivacaine is a tertiary amine used as a local anesthetic. |
| M20814 | VX-150 | VX-150 (EOS-62073) is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold). |
| M20507 | (-)-Sparteine Sulfate | Sparteine Sulfate, a quinolizidine alkaloid, is the sulfate form of sparteini, which is a sodium channel blocker used as an oxytocic and an anti-arrhythmia agent. |
| M15108 | FR183998 free base | FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively. |
| M14275 | Ropivacaine hydrochloride | Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. |
| M14274 | Riluzole hydrochloride | Riluzole hydrochloride is an anticonvulsant drug and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM. |
| M14273 | Ralfinamide | Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain. |
| M14272 | Propoxycaine hydrochloride | Propoxycaine hydrochloride inhibits voltage-gated sodium channels, and thereby inhibits the ionic flux required for the initiation and conduction of impulses. Propoxycaine hydrochloride application can lead to a loss of sensation. |
| M14271 | Eniporide hydrochloride | Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na+/H+ exchange inhibitor. |
| M14270 | Disopyramide | Disopyramide (Dicorantil) is a class IA antiarrhythmic drug with efficacy in ventricular and atrial arrhythmias. |
| M10492 | Ropivacaine | Ropivacaine is a member of the amino amide class of local anesthetics and acts as a potent sodium channel blocker. |
| M10470 | Raxatrigine hydrochloride | Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a selective, small-molecule, state-dependent Nav1.7 voltage-gated sodium channel blocker. |
| M10458 | Huwentoxin IV TFA | Huwentoxin IV TFA is a selective NaV1.7 channel blocker, which preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). |
| M10113 | BI01383298 | BI01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5). |
| M9129 | GNE-131 | GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. |
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