| Cat.No. | Name | Information |
|---|---|---|
| M3386 | Amiloride hydrochloride | Amiloride hydrochloride, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. |
| M3366 | Amiloride hydrochloride dihydrate | Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker. |
| M58140 | HwTx-IV | Huwentoxin-IV (HwTx-IV) is a 35-residue neurotoxin peptide with potential application as a novel analgesic. Huwentoxin-IV, a component of tarantula venom, potently blocks sodium channels and is an attractive scaffold for engineering a Nav1.7-selective molecule. |
| M42248 | ProTx II TFA | ProTx II TFA is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. |
| M5069 | S0859 | S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). |
| M5897 | Prilocaine | Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. |
| M10322 | GSK-2330672 (Linerixibat) | GSK-2330672, also known as linerixibat, is a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor for the research of type 2 diabetes. |
| M10113 | BI01383298 | BI01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5). |
| M9129 | GNE-131 | GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. |
| M9115 | PF-06869206 | PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM. |
| M9103 | Eleclazine hydrochloride | Eleclazine HCl is a novel late Na+ current inhibitor, with IC50 value of 0.7 uM. |
| M8988 | PF-05089771 | PF-05089771 is a selective Nav1.7 channel blocker that interacts with the voltage-sensor domain (VSD) of domain IV. |
| M8947 | PF-01247324 | PF-01247324 is a novel selective and orally bioavailable Nav 1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel. |
| M8911 | GS967 | GS967, also known as GS-458967, is a potent and selective blocker of cardiac late sodium current (late INa) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively. |
| M8428 | PF-04856264 | PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. |
| M8004 | Phenamil methanesulfonate salt | Phenamil methanesulfonate is an irreversible inhibitor of amiloride-sensitive Na+ channels; derivative of amiloride. |
| M7732 | CGP-37157 | CGP37157 is a potent, selective inhibitor of mitochondrial Na+/Ca2+ exchange as well as sarcoplasmic reticulum calcium-stimulated ATPase and possibly other calcium channels. |
| M7552 | ETH2120 | Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc. |
| M7520 | Brivaracetam | Brivaracetam (UCB 34714) is chemically related to levetiracetam (LEV, Keppra). It possesses a binding affinity for the synaptic vesicle protein 2A (SV2A) ten-fold above that of LEV and also shows an ability to inhibit Na+ channels. |
| M7463 | Veratridine | Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. |
| M7288 | SEA 0400 | SEA 0400 is a potent Na+/Ca2+ exchanger (NCX) inhibitor. |
| M7180 | QX 314 bromide | QX 314 bromide is a na+ channel blocker. |
| M6755 | GMQ hydrochloride | GMQ hydrochloride is a potent and selective modulator of acid-sensing ion channel (ASIC) that activates ASIC3 channels under neutral pH. GQM blocks acid-induced maximal peak current and alters ASICs pH dependence for activation and inactivation. |
| M6498 | Benzamil | Benzamil is a nCX inhibitor, Deg/ENaC channel blocker; amiloride derivative. |
| M6342 | 4-Chlorophenylguanidine hydrochloride | 4-Chlorophenylguanidine hydrochloride is a urokinase inhibitor. |
| M6085 | Raxatrigine | Raxatrigine (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. |
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