| Cat.No. | Name | Information |
|---|---|---|
| M3386 | Amiloride hydrochloride | Amiloride hydrochloride, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. |
| M3366 | Amiloride hydrochloride dihydrate | Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker. |
| M58140 | HwTx-IV | Huwentoxin-IV (HwTx-IV) is a 35-residue neurotoxin peptide with potential application as a novel analgesic. Huwentoxin-IV, a component of tarantula venom, potently blocks sodium channels and is an attractive scaffold for engineering a Nav1.7-selective molecule. |
| M42248 | ProTx II TFA | ProTx II TFA is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. |
| M5069 | S0859 | S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). |
| M5897 | Prilocaine | Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. |
| M10868 | Odevixibat | Odevixibat (A4250) is a potent selective ileal bile acid transporter (IBAT) inhibitor. Odevixibat (A4250) mitigates cholestatic liver and bile duct damage in mouse models. Odevixibat (A4250) can be used in the study of primary biliary cirrhosis. |
| M10567 | Acevaltrate | Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively. |
| M10470 | Raxatrigine hydrochloride | Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a selective, small-molecule, state-dependent Nav1.7 voltage-gated sodium channel blocker. |
| M10458 | Huwentoxin IV TFA | Huwentoxin IV TFA is a selective NaV1.7 channel blocker, which preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). |
| M10322 | GSK-2330672 (Linerixibat) | GSK-2330672, also known as linerixibat, is a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor for the research of type 2 diabetes. |
| M10113 | BI01383298 | BI01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5). |
| M9129 | GNE-131 | GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. |
| M9115 | PF-06869206 | PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM. |
| M9103 | Eleclazine hydrochloride | Eleclazine HCl is a novel late Na+ current inhibitor, with IC50 value of 0.7 uM. |
| M8988 | PF-05089771 | PF-05089771 is a selective Nav1.7 channel blocker that interacts with the voltage-sensor domain (VSD) of domain IV. |
| M8947 | PF-01247324 | PF-01247324 is a novel selective and orally bioavailable Nav 1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel. |
| M8911 | GS967 | GS967, also known as GS-458967, is a potent and selective blocker of cardiac late sodium current (late INa) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively. |
| M8428 | PF-04856264 | PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. |
| M8004 | Phenamil methanesulfonate salt | Phenamil methanesulfonate is an irreversible inhibitor of amiloride-sensitive Na+ channels; derivative of amiloride. |
| M7732 | CGP-37157 | CGP37157 is a potent, selective inhibitor of mitochondrial Na+/Ca2+ exchange as well as sarcoplasmic reticulum calcium-stimulated ATPase and possibly other calcium channels. |
| M7552 | ETH2120 | Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc. |
| M7520 | Brivaracetam | Brivaracetam (UCB 34714) is chemically related to levetiracetam (LEV, Keppra). It possesses a binding affinity for the synaptic vesicle protein 2A (SV2A) ten-fold above that of LEV and also shows an ability to inhibit Na+ channels. |
| M7463 | Veratridine | Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. |
| M7288 | SEA 0400 | SEA 0400 is a potent Na+/Ca2+ exchanger (NCX) inhibitor. |
| M7180 | QX 314 bromide | QX 314 bromide is a na+ channel blocker. |
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