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Preincubation of the cells with the Na+ ionophore sodium ionophore III not only stimulated caffeate reduction, but completely abolished ATP synthesis. Addition of sodium ionophore III to cells in the steady state of caffeate reduction immediately dissipated the intracellular ATP level. Lactate-sulfate grown cells are insensitive to the Na+ ionophore, ETH2120. Sodium ionophore III ligand is a very effective receptor for the Eu3+ and Am3+ cations and can be considered as a potential extraction agent for nuclear iste treatment.
| Cell Experiment | |
|---|---|
| Cell lines | Desulfovibrio alaskensis |
| Preparation method | The protonophore 3,3,4,5-tetrachlorosalicylanilide (TCS, 5 µM or 20 µM), or the sodium-specific ionophore N,N,N′,N′-Tetracyclohexyl-1,2-phenylenedioxydiacetamide (ETH2120, 20 µM) were added to media to test their effects on growth. |
| Concentrations | 20 µM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 552.79 |
| Formula | C34H52N2O4 |
| CAS Number | 81686-22-8 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Wang L, et al. PeerJ. The role of Rnf in ion gradient formation in Desulfovibrio alaskensis.
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