| Cat.No. | Name | Information |
|---|---|---|
| M3386 | Amiloride hydrochloride | Amiloride hydrochloride, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. |
| M3366 | Amiloride hydrochloride dihydrate | Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker. |
| M58140 | HwTx-IV | Huwentoxin-IV (HwTx-IV) is a 35-residue neurotoxin peptide with potential application as a novel analgesic. Huwentoxin-IV, a component of tarantula venom, potently blocks sodium channels and is an attractive scaffold for engineering a Nav1.7-selective molecule. |
| M42248 | ProTx II TFA | ProTx II TFA is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. |
| M5069 | S0859 | S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). |
| M5897 | Prilocaine | Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. |
| M42254 | Dc1a | Dc1a potently promotes opening of the German cockroach Nav channel (BgNav1). |
| M42253 | Aneratrigine hydrochloride | Aneratrigine (hydrochloride) is a sodium channel protein type 9 subunit alpha blocker. |
| M42252 | 6-Iodoamiloride | 6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. |
| M42251 | DS43260857 | DS43260857 is a potentNaV1.7inhibitor, which has a high inhibitory effect on both human and mouse NaV1.7. |
| M42250 | Nav1.3 channel inhibitor 1 | Nav1.3 channel inhibitor 1 is a state-dependent voltage-gated sodium channel Nav1.3 inhibitor (IC50=20 nM). |
| M42249 | ATX-II | ATX-II is a specific Na+ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). |
| M40702 | PF-04531083 | PF-04531083 is a selective NaV1.8 blocker for studies related to chronic pain. |
| M39045 | Cyfluthrin | Cyfluthrin is a type II pyrethroid and has effects on various insects. Cyfluthrin is a modulator of Nav1.8 sodium channels by repetitive stimulation. Cyfluthrin can be applied in agriculture,veterinary, insecticide,pyrethroid and stored product. |
| M39043 | 3-Deoxyaconitine | 3-Deoxyaconitine a diterpenoid alkaloid, is a sodium channel activator. |
| M39042 | 6-Benzoylheteratisine | 6-Benzoylheteratisine is a naturally occurring antagonist of the Na+ channel activator aconitine. |
| M31237 | Idrevloride | Idrevloride is an epithelial sodium channel (ENaC) inhibitor, can be used for the research of skin disorders. |
| M31053 | QAQ dichloride | QAQ dichloride, a photoswitchable voltage-gated Nav and Kv channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain. |
| M30982 | DPI 201-106 | DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect. |
| M30875 | XEN907 | XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain. |
| M30797 | Pilsicainide | Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent. |
| M30796 | Pilsicainide hydrochloride | Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent. |
| M30584 | Nicainoprol | Nicainoprol is a fast-sodium-channel blocking agent, which is a potent antiarrhythmic agent. |
| M29882 | NS383 | NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits. |
| M28858 | GX-201 | GX-201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7. |
| M28760 | AMG8379 | AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
