| Cat.No. | Name | Information |
|---|---|---|
| M3386 | Amiloride hydrochloride | Amiloride hydrochloride, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. |
| M3366 | Amiloride hydrochloride dihydrate | Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker. |
| M42253 | Aneratrigine hydrochloride | Aneratrigine (hydrochloride) is a sodium channel protein type 9 subunit alpha blocker. |
| M42252 | 6-Iodoamiloride | 6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. |
| M42251 | DS43260857 | DS43260857 is a potentNaV1.7inhibitor, which has a high inhibitory effect on both human and mouse NaV1.7. |
| M42250 | Nav1.3 channel inhibitor 1 | Nav1.3 channel inhibitor 1 is a state-dependent voltage-gated sodium channel Nav1.3 inhibitor (IC50=20 nM). |
| M42249 | ATX-II | ATX-II is a specific Na+ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata). |
| M42248 | ProTx II TFA | ProTx II TFA is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. |
| M40702 | PF-04531083 | PF-04531083 is a selective NaV1.8 blocker for studies related to chronic pain. |
| M39045 | Cyfluthrin | Cyfluthrin is a type II pyrethroid and has effects on various insects. Cyfluthrin is a modulator of Nav1.8 sodium channels by repetitive stimulation. Cyfluthrin can be applied in agriculture,veterinary, insecticide,pyrethroid and stored product. |
| M39044 | Bifenthrin | Bifenthrin prolongs the opening time of Nav1.8 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. |
| M39043 | 3-Deoxyaconitine | 3-Deoxyaconitine a diterpenoid alkaloid, is a sodium channel activator. |
| M39042 | 6-Benzoylheteratisine | 6-Benzoylheteratisine is a naturally occurring antagonist of the Na+ channel activator aconitine. |
| M31237 | Idrevloride | Idrevloride is an epithelial sodium channel (ENaC) inhibitor, can be used for the research of skin disorders. |
| M31053 | QAQ dichloride | QAQ dichloride, a photoswitchable voltage-gated Nav and Kv channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain. |
| M30982 | DPI 201-106 | DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect. |
| M30875 | XEN907 | XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain. |
| M30797 | Pilsicainide | Pilsicainide (SUN 1165 free acid) is a potent sodium channel blocker and potent class Ic antiarrhythmic agent. |
| M30796 | Pilsicainide hydrochloride | Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent. |
| M30584 | Nicainoprol | Nicainoprol is a fast-sodium-channel blocking agent, which is a potent antiarrhythmic agent. |
| M29882 | NS383 | NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits. |
| M28858 | GX-201 | GX-201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7. |
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