| Cat.No. | Name | Information |
|---|---|---|
| M3386 | Amiloride hydrochloride | Amiloride hydrochloride, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. |
| M3366 | Amiloride hydrochloride dihydrate | Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker. |
| M58140 | HwTx-IV | Huwentoxin-IV (HwTx-IV) is a 35-residue neurotoxin peptide with potential application as a novel analgesic. Huwentoxin-IV, a component of tarantula venom, potently blocks sodium channels and is an attractive scaffold for engineering a Nav1.7-selective molecule. |
| M42248 | ProTx II TFA | ProTx II TFA is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. |
| M5069 | S0859 | S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). |
| M5897 | Prilocaine | Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. |
| M6068 | Zonisamide | Zonisamide is an fDA-approved antiepileptic compound that blocks voltage-dependent sodium (+) and T-type calcium channels. |
| M6054 | Vinpocetine | Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease. |
| M5943 | Rufinamide | Rufinamide is a voltage-gated sodium channel blocker, used an anticonvulsant medication. |
| M5904 | Proparacaine HCl | Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM. |
| M5897 | Prilocaine | Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. |
| M5876 | Phenytoin Sodium | Phenytoin Sodium is a potent Voltage-gated Na+ channels (VGSCs) blocker. |
| M5875 | Phenytoin | Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin reduces breast tumour growth and metastasis in mice, and it also has antiepileptic activity. |
| M5699 | Ibutilide fumarate | Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. |
| M5069 | S0859 | S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). |
| M4765 | Oleandrin | Oleandrin (PBI-05204) inhibited Na+, K+ -atPase activity with IC50 of 620 nM. |
| M4339 | Bufalin | Bufalin is a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM respectively, it has anti-cancer activity. |
| M4148 | Dimethyl-lithospermate-B | Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows sodium current (INa) inactivation, resulting in an early increase in inward current of the action potential (AP). |
| M4068 | Ginsenoside-Rg3 | 20(S)-Ginsenoside Rg3 is the main ingredient of red ginseng. 20(S) -ginsenoside Rg3 inhibited Na+ and hKv1.4 channels with IC50 of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S) -ginsenoside Rg3 also inhibited Aβ, NF-κB activity and COX-2 expression. |
| M4020 | Bulleyaconi-cine-A | Bulleyaconitine A, A compound isolated from aconite, has anti-inflammatory activity and can also be used in pain relief studies. |
| M3987 | Ginsenoside Rb1 | Ginsenoside Rb1 is an ingredient in the Chinese medicine Panax ginseng. Ginsenoside inhibition Na, K-ATPase++ activityIC50 6.3±1.0 μM. Ginsenoside Rb1 also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. |
| M3436 | Furosemide | Furosemide is a tabular diuretic used in studies of congestive heart failure and edema. |
| M3412 | Propafenone hydrochloride | Propafenone HCl is a sodium-channel blocker that also has a high affinity for β-receptors (IC50 = 32 nM). It blocks transient outward potassium current (Ito) and sustained delayed rectifier K+ current (Isus) with IC50 values of 4.9 μM and 8.6 μM, respectively.In addition, Propafenone inhibits the proliferation of esophageal cancer by inducing mitochondrial dysfunction and apoptosis. |
| M3358 | Procainamide hydrochloride | Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor. |
| M3354 | Carbamazepine | Carbamazepine is a sodium channel inhibitor with an IC50 of 131 μM when treated with synaptosomes in rat brain. It can be used in trigeminal neuralgia research. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50=2 μM). |
| M3349 | Methocarbamol | Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms. |
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