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SEA 0400 is a potent Na+/Ca2+ exchanger (NCX) inhibitor. SEA0400 inhibits NCX activity in rat astrocytes, microglia and cultured neurons, canine cardiac sarcolemmal vesicles and rat cardiomyocytes (IC50 values are 5 and 8.3, 33, 90 and 92 nM, respectively). SEA0400 reduces infarct volumes and exhibits protective effects against myocardial ischemia in rats.
| Molecular Weight | 371.38 |
| Formula | C21H19F2NO3 |
| CAS Number | 223104-29-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 35 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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