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Proparacaine HCl

Cat. No. M5904
Proparacaine HCl Structure
Synonym:

Proxymetacaine Hydrochloride

Size Price Availability Quantity
50mg USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

Chemical Information
Molecular Weight 330.85
Formula C16H26N2O3.HCl
CAS Number 5875-06-9
Solubility (25°C) 66 mg/mL in water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wen Q, et al. J Toxicol Sci. Cytotoxicity of proparacaine to human corneal endothelial cells in vitro.

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Keywords: Proparacaine HCl, Proxymetacaine Hydrochloride supplier, Sodium Channel, inhibitors, activators


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