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Raxatrigine (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.
| Cell Experiment | |
|---|---|
| Cell lines | HEK cells |
| Preparation method | Activity of CNV1014802 was assessed in HEK cells heterologously expressing NaV1.1–NaV1.8 using FLIPR membrane potential assays. |
| Concentrations | 1 mM |
| Incubation time | 5 minutes |
| Animal Experiment | |
|---|---|
| Animal models | adult male C57BL/6J mice |
| Formulation | phosphate-buffered saline/10% DMSO |
| Dosages | 30 mg/kg |
| Administration | i.v. |
| Molecular Weight | 314.35 |
| Formula | C18H19FN2O2 |
| CAS Number | 934240-30-9 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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