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Bufalin

Cat. No. M4339
Bufalin Structure
Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Bufalin is a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM respectively, it has anti-cancer activity. Bufalin (2 μM) increases caspae-3, Endo G and GADD153 mRNA expression, but decreases the GRP78 mRNA expression.

In vivo, Bufalin (0.1, 0.2, or 0.4 mg/kg, i.p., daily for 14 days) shows significant anti-tumor activity in mice bearing NCI-H460 cells.

Chemical Information
Molecular Weight 386.52
Formula C24H34O4
CAS Number 465-21-4
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lei Dou, et al. Bufalin suppresses ovarian cancer cell proliferation via EGFR pathway

[2] Kai Fang, et al. Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway

[3] Shan Su, et al. Bufalin inhibits ovarian carcinoma via targeting mTOR/HIF-α pathway

[4] Min Li, et al. Bufalin-induced cardiotoxicity: new findings into mechanisms

[5] Yu-Long Lan, et al. A research update on the anticancer effects of bufalin and its derivatives

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