All AbMole products are for research use only, cannot be used for human consumption.
Bufalin is a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM respectively, it has anti-cancer activity. Bufalin (2 μM) increases caspae-3, Endo G and GADD153 mRNA expression, but decreases the GRP78 mRNA expression.
In vivo, Bufalin (0.1, 0.2, or 0.4 mg/kg, i.p., daily for 14 days) shows significant anti-tumor activity in mice bearing NCI-H460 cells.
| Molecular Weight | 386.52 |
| Formula | C24H34O4 |
| CAS Number | 465-21-4 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Lei Dou, et al. Bufalin suppresses ovarian cancer cell proliferation via EGFR pathway
[3] Shan Su, et al. Bufalin inhibits ovarian carcinoma via targeting mTOR/HIF-α pathway
[4] Min Li, et al. Bufalin-induced cardiotoxicity: new findings into mechanisms
[5] Yu-Long Lan, et al. A research update on the anticancer effects of bufalin and its derivatives
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