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S0859 is an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). Na(+)-coupled HCO(3)(-) transporters (NBCs) mediate the transport of bicarbonate ions across cell membranes and are thus ubiquitous regulators of intracellular pH.
BioRxiv. 2024 Oct 15.
Functional contribution of astrocytic Kir4.1 channels to spasticity after spinal cord injury
S0859 purchased from AbMole
| Molecular Weight | 530.04 |
| Formula | C29H24ClN3O3S |
| CAS Number | 1019331-10-2 |
| Solubility (25°C) | 43 mg/ml in CHCL3 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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