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GSK-2330672, also known as linerixibat, is a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (IC50 = 42 nM) for the research of type 2 diabetes. In vivo, Linerixibat (0.05-10 mg/kg; oral gavage; twice daily for 14 days) treatment on male ZDF rat lowers glucose in an animal model of type 2 diabetes.
| Molecular Weight | 546.68 |
| Formula | C28H38N2O7S |
| CAS Number | 1345982-69-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 37 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Sodium Channel Products |
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5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively. |
| HwTx-IV
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