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PF-05089771 is a Nav1.7 channel blocker with IC50s of 8, 11 and 171 nM for mouse, human and rat Nav1.7, respectively. PF-05089771 exhibits selectivity over a panel of 81 other ion channels, receptors, enzymes and transporters. PF-05089771 blocks spontaneous firing of inherited erythromelalgia (IEM)-derived iPSC sensory neurons in vitro.
| Molecular Weight | 500.35 |
| Formula | C18H12Cl2FN5O3S2 |
| CAS Number | 1235403-62-9 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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