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Ferrostatin-1

Cat. No. M2698
Ferrostatin-1  Structure
Synonym:

Fer-1

Size Price Availability Quantity
5mg USD 53.1  USD59 In stock
10mg USD 93.6  USD104 In stock
25mg USD 198  USD220 In stock
50mg USD 340.2  USD378 In stock
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Quality Control
Biological Activity

Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. Ferrostatin-1 (2 μM) prevents erastin-induced ferroptosis in cancer cells, as well as glutamate-induced cell death in postnatal rat brain slices. Ferrostatin-1 is a lipid ROS scavenger, with the N-cyclohexyl moiety serving as a lipo-philic anchor within biological membranes. Ferrostatin-1 does not inhibit extracellular signal -regulated kinase (ERK) phos-phorylation or arrest the proliferation of HT-1080 cells, suggesting that it does not inhibit the MEK/ERK pathway, chelate iron, or inhibit protein synthesis. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 readily oxidizes the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) under cell-free conditions.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 262.35
Formula C15H22N2O2
CAS Number 347174-05-4
Purity 98.64%
Solubility DMSO 40 mg/mL
Storage -20°C, protect from light, dry, sealed
References

Ferrous but not ferric iron sulfate kills photoreceptors and induces photoreceptor-dependent RPE autofluorescence
Wanting Shu, et al. Redox Biol. 2020 Jul;34:101469. PMID: 32362442.

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis
Pengfei Liu, et al. Cell Mol Biol Lett. 2020 Feb 27;25:10. PMID: 32161620.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ferrostatin-1 , Fer-1 supplier, Ferroptosis, inhibitors

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