About 19 results found for searched term "Ferroptosis" (0.085 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2679 | Erastin | Ferroptosis |
| Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M2698 | Ferrostatin-1 | Ferroptosis |
| Fer-1 | ||
| Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. | ||
| M3497 | Simvastatin (MK 733) | Autophagy |
| MK 733; MK-0733 | ||
| Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. | ||
| M7434 | Trolox | ROS |
| Trolox is a vitamin E analogue that has powerful antioxidant properties. Trolox is a scavenger of ROS. Trolox is also a ferroptosis inhibitor. | ||
| M7504 | CIL56 (CA3) | Ferroptosis |
| CIL56 (CA3) is a potent and selective ferroptosis inducer, it has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. | ||
| M8531 | Liproxstatin-1 | Ferroptosis |
| Lip-1 | ||
| Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). | ||
| M9060 | RSL3 | Ferroptosis |
| 1S,3R-RSL3 | ||
| RSL3 is an inhibitor of the glutathione (GSH) peroxidase 4, and a ferroptosis activator, which can inhibit the cysteine/glutamate amino acid transporter system. | ||
| M9404 | UAMC-3203 hydrochloride | Ferroptosis |
| UAMC-3203 HCl | ||
| UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor, with an IC50 of 12 nM. | ||
| M10586 | JKE-1674 | Ferroptosis |
| JKE1674 | ||
| JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1. | ||
| M10626 | UAMC-3203 | Ferroptosis |
| UAMC3203 | ||
| UAMC-3203 is an improved ferroptosis inhibitor, with an IC50 value of 10 nM in IMR-32 neuroblastoma cells. | ||
| M11044 | SRS16-86 | Ferroptosis |
| SRS16-86 is a potent inhibitor of ferroptosis. SRS16-86 is more metabolically and plasma-stable in vivo than Ferrostatin-1. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) studies. | ||
| M11314 | iFSP1 | Ferroptosis |
| IFSP1 is an effective, selective and glutathione-independent inhibitor of ferroptosis Suppressor protein 1 (FSP1/AIFM2) with an EC50 value of 103 nM. IFSP1 can selectively induce iron death in Pfa1 cells and HT1080 cells with GPX4 knockout gene overexpressing FSP1. | ||
| M11328 | FINO2 | Ferroptosis |
| A ferroptosis inducer. | ||
| M13544 | Ammonium iron(III) citrate | Ferroptosis |
| Ammonium ferric citrate; FAC | ||
| Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production. | ||
| M21708 | Erastin2 | Ferroptosis |
| Erastin2 is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter. | ||
| M27956 | EPI-743 | Mitochondrial Related |
| α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075 | ||
| EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione. | ||
| M29297 | PKUMDL-LC-101-D04 | Glutathione Peroxidase |
| GPX4-Activator-1d4 | ||
| PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts. | ||
| M29325 | BODIPY 581/591 C11 | Fluorescent Dye |
| BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type). | ||
| M39011 | W1131 | STAT |
| W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU. W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway. | ||
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