About 30 results found for searched term "Ferroptosis" (0.098 seconds)
Cat.No. | Name | Target |
---|---|---|
M10244 | Imidazole ketone erastin | Ferroptosis |
Ferroptosis inducer IKE; PUN-30119 | ||
Imidazole Ketone Erastin (IKE) is an inducer for ferroptosis iron death. It is also a potent, selective, and metabolically stable system XC -- inhibitor. IKE is more water-soluble than Erastin. Inducing iron death in diffuse large B-cell lymphoma cells (e.g. Sudhl-5/6/16). | ||
M2197 | Sulfasalazine | Ferroptosis |
Salazopyrin; Azulfidine; Sulphasalazine; SAS; NSC 667219 | ||
Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. | ||
M2355 | 1-Hexadecanol | Others |
Palmityl alcohol | ||
1-Hexadecanol is a fatty alcohol used to make other chemicals. 1-hexadecanol acts as a ferroptosis activator. | ||
M2679 | Erastin | Ferroptosis |
Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, freshly prepared is recommended | ||
M2698 | Ferrostatin-1 | Ferroptosis |
Fer-1 | ||
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. | ||
M3026 | Sorafenib (BAY 43-9006) | Raf |
BAY 43-9006 | ||
Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. Sorafenib is a multikinase inhibitor with IC50 values of 15 nM, 20 nM, 57 nM and 58 nM for VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib is a ferroptosis activator. | ||
M3497 | Simvastatin (MK 733) | Autophagy |
MK 733; MK-0733 | ||
Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. | ||
M5473 | Butylhydroxyanisole | ROS |
Butylated hydroxyanisole; BHA; E320 | ||
Butylhydroxyanisole is an antioxidant, consisting of a mixture of two isomeric organic compounds. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development. Butylhydroxyanisole is also a ferroptosis inducer. | ||
M7434 | Trolox | ROS |
Trolox is a vitamin E analogue that has powerful antioxidant properties. Trolox is a scavenger of ROS. Trolox is also a ferroptosis inhibitor. | ||
M7504 | CIL56 (CA3) | Ferroptosis |
CIL56 (CA3) is a potent and selective ferroptosis inducer, it has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. | ||
M7633 | Bicyclol | NF-κB |
SY801 | ||
Bicyclol regulates the expression of heat shock proteins and plays an anti-apoptosis role in hepatocytes. Bicyclol reduces the activation of NF-κB and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the ROS-MAPK-NF-κB pathway, and prevents ferroptosis in acute liver injury. Dicyclol is an anti-hepatitis compound used in studies of chronic hepatitis B and C in China. | ||
M8531 | Liproxstatin-1 | Ferroptosis |
Lip-1 | ||
Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). | ||
M9060 | RSL3 | Ferroptosis |
1S,3R-RSL3 | ||
RSL3 is an inhibitor of the glutathione (GSH) peroxidase 4, and a ferroptosis activator, which can inhibit the cysteine/glutamate amino acid transporter system. | ||
M9404 | UAMC-3203 hydrochloride | Ferroptosis |
UAMC-3203 HCl | ||
UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor, with an IC50 of 12 nM. | ||
M10586 | JKE-1674 | Ferroptosis |
JKE1674 | ||
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1. | ||
M10626 | UAMC-3203 | Ferroptosis |
UAMC3203 | ||
UAMC-3203 is an improved ferroptosis inhibitor, with an IC50 value of 10 nM in IMR-32 neuroblastoma cells. | ||
M11044 | SRS16-86 | Ferroptosis |
SRS16-86 is a potent inhibitor of ferroptosis. SRS16-86 is more metabolically and plasma-stable in vivo than Ferrostatin-1. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) studies. | ||
M11314 | iFSP1 | Ferroptosis |
IFSP1 is an effective, selective and glutathione-independent inhibitor of ferroptosis Suppressor protein 1 (FSP1/AIFM2) with an EC50 value of 103 nM. IFSP1 can selectively induce iron death in Pfa1 cells and HT1080 cells with GPX4 knockout gene overexpressing FSP1. | ||
M11328 | FINO2 | Ferroptosis |
FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation. | ||
M45075 | Ferroptocide | Ferroptosis |
Ferroptocide is a small molecule inhibitor of thioredoxin, as well as an inducer of ferroptosis, with antitumor activity. | ||
M13544 | Ammonium iron(III) citrate | Ferroptosis |
Ferric Ammonium Citrate; FAC; AFC | ||
Ammonium iron(III) citrate (Ferric Ammonium Citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production. | ||
M15074 | Pipecolic acid | Metabolite/Endogenous Metabolite |
piperidine-2-carboxylic acid | ||
Pipecolic acid, a lysine metabolite, is an important immunomodulator in plants and humans, and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy. | ||
M17784 | Oleanonic acid | Triterpenoids |
Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats. | ||
M21708 | Erastin2 | Ferroptosis |
Erastin2 is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter. | ||
M27956 | EPI-743 | Mitochondrial Related |
α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075 | ||
EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione. | ||
M29297 | PKUMDL-LC-101-D04 | Glutathione Peroxidase |
GPX4-Activator-1d4; PKU | ||
PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts. | ||
M29325 | ABDP 581/591 C11 | Fluorescent Dye |
ABDP C11 | ||
ABDP 581/591 C11 (same as BODIPY 581/591 C11) is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. ABDP 581/591 C11 (same as BODIPY 581/591 C11) can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. ABDP 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type). | ||
M39011 | W1131 | STAT |
W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU. W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway. | ||
M41344 | Lepadin E | Glutathione Peroxidase |
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. | ||
M41345 | Moracin N | Glutathione Peroxidase |
Moracin N is a ferroptosis inhibitor that can be isolated from mulberry leaf. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.