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Cat. No. M21708
Erastin2 Structure
Size Price Availability Quantity
5mg USD 180  USD180 In stock
10mg USD 295  USD295 In stock
25mg USD 560  USD560 In stock
50mg USD 820  USD820 In stock
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Quality Control & Documentation
Biological Activity

Erastin2 is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter.

Chemical Information
Molecular Weight 623.14
Formula C36H35ClN4O4
CAS Number 1695533-44-8
Solubility (25°C) DMSO 90 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Michelle Riegman, et al. Nat Cell Biol. Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture

[2] Jennifer Yinuo Cao, et al. Cell Rep . A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

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Keywords: Erastin2 supplier, Ferroptosis, inhibitors, activators

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