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Ferroptosis Ferroptosis

Cat.No.  Name Information
M9060 RSL3 RSL3 is an inhibitor of the glutathione (GSH) peroxidase 4, and a ferroptosis activator, which can inhibit the cysteine/glutamate amino acid transporter system.
M5558 Deferoxamine mesylate Deferoxamine mesylate as a chelating agent used to remove excess iron from the body.
M2698 Ferrostatin-1 Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.
M2679 Erastin Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, freshly prepared is recommended
M21708 Erastin2 Erastin2 is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter.
M13546 Ethylenediaminetetraacetic acid trisodium salt Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt) is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia.
M13545 DL-Buthionine-(S,R)-sulfoximine DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
M13544 Ammonium iron(III) citrate Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production.
M11328 FINO2 A ferroptosis inducer.
M11314 iFSP1 IFSP1 is an effective, selective and glutathione-independent inhibitor of ferroptosis Suppressor protein 1 (FSP1/AIFM2) with an EC50 value of 103 nM. IFSP1 can selectively induce iron death in Pfa1 cells and HT1080 cells with GPX4 knockout gene overexpressing FSP1.
M11044 SRS16-86 SRS16-86 is a potent inhibitor of ferroptosis. SRS16-86 is more metabolically and plasma-stable in vivo than Ferrostatin-1. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) studies.
M10626 UAMC-3203 UAMC-3203 is an improved ferroptosis inhibitor, with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.
M10587 ML162 ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces iron death and has shown cytotoxic effects against melanoma, lung adenocarcinoma, fibrosarcoma, and pancreatic cancer cell lines.
M10586 JKE-1674 JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1.
M10244 Imidazole ketone erastin Imidazole Ketone Erastin (IKE) is an inducer for ferroptosis iron death. It is also a potent, selective, and metabolically stable system XC -- inhibitor. IKE is more water-soluble than Erastin. Inducing iron death in diffuse large B-cell lymphoma cells (e.g. Sudhl-5/6/16).
M9929 Ammonium chloride Ammonium chloride is mainly used in medicine, dry battery, fabric printing and dyeing, fertilizer, leather tanning, electroplating, detergent, etc.
M9404 UAMC-3203 hydrochloride UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor, with an IC50 of 12 nM.
M8531 Liproxstatin-1 Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS).
M7504 CIL56 (CA3) CIL56 (CA3) is a potent and selective ferroptosis inducer, it has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties.
M7104 PD 146176 PD 146176 is a selective 15-lipoxygenase inhibitor.




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