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Ferroptosis Ferroptosis

Cat.No.  Name Information
M9929 Ammonium chloride Ammonium chloride is mainly used in medicine, dry battery, fabric printing and dyeing, fertilizer, leather tanning, electroplating, detergent, etc.
M9060 RSL3 RSL3 is an inhibitor of the glutathione (GSH) peroxidase 4, and a ferroptosis activator, which can inhibit the cysteine/glutamate amino acid transporter system.
M3865 L-Buthionine-sulfoximine L-buthionine-sulfoximine is a cell-permeable, potent, fast-acting, irreversible g-glutamylcysteine synthetase inhibitor that consumes endogenous endogenous intracellular copper chelating agent glutathione. Sensitized cells to cell death induced by Elesclomol-copper, and the efficacy of statin inhibitors was enhanced by combination.
M2698 Ferrostatin-1 Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.
M2679 Erastin Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, freshly prepared is recommended
M55221 Butylated hydroxytoluene Butylated hydroxytoluene is an antioxidant. Butylated hydroxytoluene is a ferroptosis inhibitor.
M45392 MMRi62 MMRi62 is a ferroptosis inducer targeting MDM2-MDM4 (negative regulator of the oncogene p53), which induces ferroptosis accompanied by an increase in reactive oxygen species (ROS) and lysosomal degradation of ferritin heavy chain (FTH1).MMRi62 displays p53-independent apoptosis activity and induces autophagy in pancreatic ductal adenocarcinoma (PDAC) cells. MMRi62 shows p53-independent pro-apoptosis activity and induces autophagy in pancreatic ductal adenocarcinoma (PDAC) cells.) In addition, MMRi62 caused proteasomal degradation of mutant p53 and was active in vivo in an in situ xenograft PDAC mouse model characterized by high-frequency mutations in KRAS and TP53.
M45069 Piperazine Erastin Piperazine Erastin is an Erastin derivative and an inducer of ferroptosis. Piperazine erastin induces an iron-dependent form of non-apoptotic cell death.
M43932 N6F11 N6F11 is a novel ferroptosis inducer that selectively triggers the ubiquitination degradation of GPX4 by binding to the specific structural domain of TRIM25, a ubiquitinated E3 ligase, which is expressed in tumor cells, leading to ferroptosis in cancer cells.
M21708 Erastin2 Erastin2 is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter.
M18414 7-Dehydrocholesterol 7-Dehydrocholesterol (7-DHC) is a metabolic intermediate in cholesterol synthesis as well as an unsaturated sterol whose conjugated double bond on the sterol's B ring allows 7-DHC to take up free radicals, thereby counteracting the ability of free radicals to trigger lipid oxidation and iron death.
M13546 Ethylenediaminetetraacetic acid trisodium salt Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt) is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia.
M13545 DL-Buthionine-(S,R)-sulfoximine DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
M13544 Ammonium iron(III) citrate Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production.
M11328 FINO2 A ferroptosis inducer.
M11314 iFSP1 IFSP1 is an effective, selective and glutathione-independent inhibitor of ferroptosis Suppressor protein 1 (FSP1/AIFM2) with an EC50 value of 103 nM. IFSP1 can selectively induce iron death in Pfa1 cells and HT1080 cells with GPX4 knockout gene overexpressing FSP1.
M11044 SRS16-86 SRS16-86 is a potent inhibitor of ferroptosis. SRS16-86 is more metabolically and plasma-stable in vivo than Ferrostatin-1. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) studies.
M10626 UAMC-3203 UAMC-3203 is an improved ferroptosis inhibitor, with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.
M10587 ML162 ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces iron death and has shown cytotoxic effects against melanoma, lung adenocarcinoma, fibrosarcoma, and pancreatic cancer cell lines.
M10586 JKE-1674 JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1.

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