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ML162

Cat. No. M10587
ML162 Structure
Synonym:

ML-162

Size Price Availability Quantity
5mg USD 110  USD110 In stock
10mg USD 165  USD165 In stock
25mg USD 340  USD340 In stock
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Quality Control & Documentation
Biological Activity

ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces iron death and has shown cytotoxic effects against melanoma, lung adenocarcinoma, fibrosarcoma, and pancreatic cancer cell lines.

Chemical Information
Molecular Weight 477.40
Formula C23H22Cl2N2O3S
CAS Number 1035072-16-2
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Daiha Shin, et al. Free Radic Biol Med. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

[2] Michel Weiwer, et al. Bioorg Med Chem Lett. Development of small-molecule probes that selectively kill cells induced to express mutant RAS

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Keywords: ML162, ML-162 supplier, Ferroptosis, inhibitors, activators

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