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Cat. No. M10587
ML162 Structure


Size Price Availability Quantity
1mg USD 50  USD50 In stock
5mg USD 95  USD95 In stock
10mg USD 145  USD145 In stock
25mg USD 290  USD290 In stock
50mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces iron death and has shown cytotoxic effects against melanoma, lung adenocarcinoma, fibrosarcoma, and pancreatic cancer cell lines.

Chemical Information
Molecular Weight 477.40
Formula C23H22Cl2N2O3S
CAS Number 1035072-16-2
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Daiha Shin, et al. Free Radic Biol Med. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

[2] Michel Weiwer, et al. Bioorg Med Chem Lett. Development of small-molecule probes that selectively kill cells induced to express mutant RAS

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Abmole Inhibitor Catalog

Keywords: ML162, ML-162 supplier, Ferroptosis, inhibitors, activators

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