Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3).
*The compound is unstable in solutions, freshly prepared is recommended
JPI. 2024 Jan-Feb;67(1):p 47-56.
Fatty Acid Binding Protein-4 Silencing Inhibits Ferroptosis to Alleviate Lipopolysaccharide-induced Injury of Renal Tubular Epithelial Cells by Blocking Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling
Erastin purchased from AbMole
Asian Journal of Pharmaceutical Sciences. 2023 Nov.
Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma
Erastin purchased from AbMole
Oxid Med Cell Longev. 2023 Jan 14;2023:6896790.
Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression
Erastin purchased from AbMole
Cancer Cell Int. 2023 Jan 13;23(1):5.
Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote
Erastin purchased from AbMole
Apoptosis. 2023 Apr;28(3-4):607-626.
Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1
Erastin purchased from AbMole
Arthritis Res Ther. 2023 Oct 26;25(1):212.
ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model
Erastin purchased from AbMole
Oxid Med Cell Longev. 2022 Apr 16;2022:4505513.
Nrf2-Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute-on-Chronic Liver Failure
Erastin purchased from AbMole
Front Pharmacol. 2022 Oct 18;13:1026641.
Platelet-rich plasma ameliorates lipopolysaccharide-induced cardiac injury by inflammation and ferroptosis regulation
Erastin purchased from AbMole
J Clin Invest. 2021 Nov 15;131(22):e152067.
RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11
Erastin purchased from AbMole
Molecular Weight | 547.04 |
Formula | C30H31ClN4O4 |
CAS Number | 571203-78-6 |
Solubility (25°C) | DMSO ≥ 10 mg/mL (Need ultrasonic) |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Jing Du, et al. Redox Biol. Identification of Frataxin as a regulator of ferroptosis
[4] Y Xie, et al. Cell Death Differ. Ferroptosis: process and function
[5] Scott J Dixon, et al. Cell. Ferroptosis: an iron-dependent form of nonapoptotic cell death
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PRDX3(103-112) SO3 modified, human
PRDX3(103-112) SO3 modified, human is a marker of ferroptosis, and can be used for liver diseases study. |
PRDX3(103-112), human
PRDX3(103-112), human is a marker for ferroptosis. |
GPX4-IN-3
GPX4-IN-3 is a potent glutathione peroxidase 4 (GPX4) inhibitor that selectively induces ferroptosis.1 μM of GPX4-IN-3 inhibited 71.7% of GPX4 activity. |
YL-939
YL-939 is a potent ferroptosis inhibitor that inhibits iron death by targeting the PHB2/ferritin/iron axis. |
MMRi62
MMRi62 is a ferroptosis inducer targeting MDM2-MDM4 (negative regulator of the oncogene p53), which induces ferroptosis accompanied by an increase in reactive oxygen species (ROS) and lysosomal degradation of ferritin heavy chain (FTH1).MMRi62 displays p53-independent apoptosis activity and induces autophagy in pancreatic ductal adenocarcinoma (PDAC) cells. MMRi62 shows p53-independent pro-apoptosis activity and induces autophagy in pancreatic ductal adenocarcinoma (PDAC) cells.) In addition, MMRi62 caused proteasomal degradation of mutant p53 and was active in vivo in an in situ xenograft PDAC mouse model characterized by high-frequency mutations in KRAS and TP53. |
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