All AbMole products are for research use only, cannot be used for human consumption.
Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3).
*The compound is unstable in solutions, freshly prepared is recommended
Cell Metab. 2024 Nov 01.
Microbiota-derived lysophosphatidylcholine alleviates Alzheimer’s disease pathology via suppressing ferroptosis
Erastin purchased from AbMole
Sci Total Environ. 2024 Nov 15;951:175612.
SAP130 mediates crosstalk between hepatocyte ferroptosis and M1 macrophage polarization in PFOS-induced hepatotoxicity
Erastin purchased from AbMole
Phytomedicine. 2024 Sep 27.
Naringenin alleviates intestinal ischemia/reperfusion injury by inhibiting ferroptosis via targeting YAP/STAT3 signaling axis
Erastin purchased from AbMole
JPI. 2024 Jan-Feb;67(1):p 47-56.
Fatty Acid Binding Protein-4 Silencing Inhibits Ferroptosis to Alleviate Lipopolysaccharide-induced Injury of Renal Tubular Epithelial Cells by Blocking Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling
Erastin purchased from AbMole
Asian Journal of Pharmaceutical Sciences. 2023 Nov.
Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma
Erastin purchased from AbMole
Oxid Med Cell Longev. 2023 Jan 14;2023:6896790.
Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression
Erastin purchased from AbMole
Cancer Cell Int. 2023 Jan 13;23(1):5.
Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote
Erastin purchased from AbMole
Apoptosis. 2023 Apr;28(3-4):607-626.
Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1
Erastin purchased from AbMole
Arthritis Res Ther. 2023 Oct 26;25(1):212.
ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model
Erastin purchased from AbMole
Oxid Med Cell Longev. 2022 Apr 16;2022:4505513.
Nrf2-Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute-on-Chronic Liver Failure
Erastin purchased from AbMole
Front Pharmacol. 2022 Oct 18;13:1026641.
Platelet-rich plasma ameliorates lipopolysaccharide-induced cardiac injury by inflammation and ferroptosis regulation
Erastin purchased from AbMole
J Clin Invest. 2021 Nov 15;131(22):e152067.
RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11
Erastin purchased from AbMole
Molecular Weight | 547.04 |
Formula | C30H31ClN4O4 |
CAS Number | 571203-78-6 |
Solubility (25°C) | DMSO ≥ 10 mg/mL (Need ultrasonic) |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Jing Du, et al. Redox Biol. Identification of Frataxin as a regulator of ferroptosis
[4] Y Xie, et al. Cell Death Differ. Ferroptosis: process and function
[5] Scott J Dixon, et al. Cell. Ferroptosis: an iron-dependent form of nonapoptotic cell death
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icFSP1
icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. |
(R)-HTS-3
(R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. |
CuATSP
CuATSP is a potent inhibitor of ferroptosis. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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