Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3).
*The compound is unstable in solutions, freshly prepared is recommended
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO ≥ 10 mg/mL (Need ultrasonic)|
Ferroptosis: process and function
Y Xie, et al. Cell Death Differ. 2016 Mar;23(3):369-79. PMID: 26794443.
Ferroptosis: an iron-dependent form of nonapoptotic cell death
Scott J Dixon, et al. Cell. 2012 May 25;149(5):1060-72. PMID: 22632970.
|Related Ferroptosis Products|
|Imidazole ketone erastin
Imidazole ketone erastin (IKE) is an inducer of ferroptosis, and it is also a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system Xc-.
UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor, with an IC50 of 12 nM.
RSL3 is an inhibitor of the glutathione (GSH) peroxidase 4, which can inhibit the cysteine/glutamate amino acid transporter system.
Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS).
CIL56 (CA3) is a potent and selective ferroptosis inducer, it has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties.
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