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Erastin

Cat. No. M2679

All AbMole products are for research use only, cannot be used for human consumption.

Erastin Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
1mg USD 40  USD40 In stock
5mg USD 90  USD90 In stock
1mg x 5 USD 108  USD108 In stock
10mg USD 135  USD135 In stock
1mg x 10 USD 180  USD180 In stock
50mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3).

*The compound is unstable in solutions, freshly prepared is recommended

Product Citations
Chemical Information
Molecular Weight 547.04
Formula C30H31ClN4O4
CAS Number 571203-78-6
Solubility (25°C) DMSO ≥ 10 mg/mL (Need ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yu-Ting Bai, et al. Int J Med Sci. Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation

[2] Jing Du, et al. Redox Biol. Identification of Frataxin as a regulator of ferroptosis

[3] Yan Yu, et al. Mol Cell Oncol. The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents

[4] Y Xie, et al. Cell Death Differ. Ferroptosis: process and function

[5] Scott J Dixon, et al. Cell. Ferroptosis: an iron-dependent form of nonapoptotic cell death

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Keywords: Erastin supplier, Ferroptosis, inhibitors, activators

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