All AbMole products are for research use only, cannot be used for human consumption.
L-buthionine-sulfoximine is a cell-permeable, potent, fast-acting, irreversible g-glutamylcysteine synthetase inhibitor that consumes endogenous endogenous intracellular copper chelating agent glutathione. Sensitized cells to cell death induced by Elesclomol-copper, and the efficacy of statin inhibitors was enhanced by combination.L-buthionine-sulfoximine is a cell-permeable, potent, fast-acting, irreversible g-glutamylcysteine synthetase inhibitor that consumes endogenous endogenous intracellular copper chelating agent glutathione. Sensitized cells to cell death induced by Elesclomol-copper, and the efficacy of statin inhibitors was enhanced by combination.
Cell Metab. 2024 Oct 18.
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex
L-Buthionine-sulfoximine purchased from AbMole
J Control Release. 2022 Jul;347:55-67.
Rapid synthesis of 'yolk-shell'-like nanosystem for MR molecular and chemo-radio sensitization
L-Buthionine-sulfoximine purchased from AbMole
| Molecular Weight | 222.31 |
| Formula | C8H18N2O3S |
| CAS Number | 83730-53-4 |
| Solubility (25°C) | Water: ≥ 30 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Deferiprone is the only orally active iron-chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. |
| Erastin
Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, it must be prepared freshly and used immediately. |
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Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
| Lithocholic acid
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| Idebenone
Idebenone, a mitochondrial protector, has neuroprotective properties and can be used to study Alzheimer's disease, Huntington's disease, and can cross the blood-brain barrier. Idebenone (oxidized form) inhibited arachidonic acid enzyme metabolism in astrocyte homogenates (IC50=16.65 μM). Idebenone is a coenzyme Q10 analogue and antioxidant that induces apoptosis (apoptotic) in human dopaminergic neuroblastoma SHSY-5Y cells. |
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Products are for research use only. Not for human use. We do not sell to patients.
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