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L-Buthionine-sulfoximine

Cat. No. M3865

All AbMole products are for research use only, cannot be used for human consumption.

L-Buthionine-sulfoximine Structure
Synonym:

L-Buthionine-(S,R)-sulfoximine; L-BSO

Size Price Availability Quantity
10mM*1mL in Water USD 60  USD60 In stock
10mg USD 30  USD30 In stock
50mg USD 50  USD50 In stock
100mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

L-buthionine-sulfoximine is a cell-permeable, potent, fast-acting, irreversible g-glutamylcysteine synthetase inhibitor that consumes endogenous endogenous intracellular copper chelating agent glutathione. Sensitized cells to cell death induced by Elesclomol-copper, and the efficacy of statin inhibitors was enhanced by combination.L-buthionine-sulfoximine is a cell-permeable, potent, fast-acting, irreversible g-glutamylcysteine synthetase inhibitor that consumes endogenous endogenous intracellular copper chelating agent glutathione. Sensitized cells to cell death induced by Elesclomol-copper, and the efficacy of statin inhibitors was enhanced by combination.


Product Citations
Chemical Information
Molecular Weight 222.31
Formula C8H18N2O3S
CAS Number 83730-53-4
Solubility (25°C) Water: ≥ 30 mg/mL (Need ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Reliene R, et al. Carcinogenesis. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice.

[2] Fruehauf JP, et al. Pigment Cell Res. Selective and synergistic activity of L-S,R-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferase.

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  Catalog
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Keywords: L-Buthionine-sulfoximine, L-Buthionine-(S,R)-sulfoximine; L-BSO supplier, Ferroptosis, inhibitors, activators

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