Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant. Idebenone is used for the treatment of Alzheimer’s disease and other cognitive defects. Idebenone inhibits lipoperoxide formation, is a synthetic analog of coenzyme Q10 (CoQ10). Idebenone increases brain energy levels and rejuvinates cell mitochondria throughout the whole body. Most recently, idebenone has been shown to be very supportive in the treatment of Friedreich’s ataxia and Duchenne muscular dystrophy. Chemically, idebenone is an organic compound of the quinone family. Idebenone has properties similar to CoQ10 in its antioxidant properties, and has therefore been used in anti-aging on the basis of free-radical theory.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO 60 mg/mL|
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