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Idebenone

Cat. No. M3400
Idebenone Structure
Synonym:

CV-2619

Size Price Availability Quantity
10mM*1mL USD 45  USD50 In stock
10mg USD 40.5  USD45 In stock
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Quality Control
Biological Activity

Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant. Idebenone is used for the treatment of Alzheimer’s disease and other cognitive defects. Idebenone inhibits lipoperoxide formation, is a synthetic analog of coenzyme Q10 (CoQ10). Idebenone increases brain energy levels and rejuvinates cell mitochondria throughout the whole body. Most recently, idebenone has been shown to be very supportive in the treatment of Friedreich’s ataxia and Duchenne muscular dystrophy. Chemically, idebenone is an organic compound of the quinone family. Idebenone has properties similar to CoQ10 in its antioxidant properties, and has therefore been used in anti-aging on the basis of free-radical theory.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 338.44
Formula C19H30O5
CAS Number 58186-27-9
Purity >98%
Solubility DMSO 60 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Idebenone, CV-2619 supplier, Ferroptosis, inhibitors

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