All AbMole products are for research use only, cannot be used for human consumption.
NCOA4-9a (NCOA4-FTH1 inhibitor 9a) is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. NCOA4-9a effectively blocks RSL3-induced ferroptosis in HT22 cells (EC50 = 3.66 μM).
NCOA4-9a directly binds to recombinant protein NCOA4383–522 (Kd=7.48 uM) and effectively blocks the NCOA4383–522–FTH1 interaction. NCOA4-9a is a selective ferroptosis inhibitor that effectively suppresses lipid peroxidation and rescues cells from ferroptosis. NCOA4-9a inhibits lysosomal ferritin degradation and localizes in autophagosomes.
NCOA4-9a significantly ameliorates the ischemic-refusion injury in rat model of ischemic stroke.
| Molecular Weight | 441.54 |
| Formula | C27H28FN5 |
| CAS Number | 2650557-72-3 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | -20°C |
| Related Ferroptosis Products |
|---|
| HBED
HBED is a potent iron chelator. |
| viFSP1
viFSP1 is a species-independent inhibitor of FSP1 that induces ferroptosis in FSP1-dependent cells. |
| icFSP1
icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. |
| (R)-HTS-3
(R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. |
| CuATSP
CuATSP is a potent inhibitor of ferroptosis. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
