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NCOA4-9a (NCOA4-FTH1 inhibitor 9a) is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. NCOA4-9a effectively blocks RSL3-induced ferroptosis in HT22 cells (EC50 = 3.66 μM).
NCOA4-9a directly binds to recombinant protein NCOA4383–522 (Kd=7.48 uM) and effectively blocks the NCOA4383–522–FTH1 interaction. NCOA4-9a is a selective ferroptosis inhibitor that effectively suppresses lipid peroxidation and rescues cells from ferroptosis. NCOA4-9a inhibits lysosomal ferritin degradation and localizes in autophagosomes.
NCOA4-9a significantly ameliorates the ischemic-refusion injury in rat model of ischemic stroke.
| Molecular Weight | 441.54 |
| Formula | C27H28FN5 |
| CAS Number | 2650557-72-3 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | -20°C |
| Related Ferroptosis Products |
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| Deferiprone
Deferiprone is the only orally active iron-chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. |
| Erastin
Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, it must be prepared freshly and used immediately. |
| Ferrostatin-1
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
| Lithocholic acid
Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption, can also activate the vitamin D receptor. |
| Idebenone
Idebenone, a mitochondrial protector, has neuroprotective properties and can be used to study Alzheimer's disease, Huntington's disease, and can cross the blood-brain barrier. Idebenone (oxidized form) inhibited arachidonic acid enzyme metabolism in astrocyte homogenates (IC50=16.65 μM). Idebenone is a coenzyme Q10 analogue and antioxidant that induces apoptosis (apoptotic) in human dopaminergic neuroblastoma SHSY-5Y cells. |
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