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N6F11

Cat. No. M43932

All AbMole products are for research use only, cannot be used for human consumption.

N6F11 Structure
Synonym:

2-(chloromethyl)-6-(4-chlorophenyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one

Size Price Availability Quantity
5mg USD 42  USD42 In stock
10mg USD 63  USD63 In stock
25mg USD 105  USD105 In stock
50mg USD 165  USD165 In stock
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Quality Control & Documentation
Biological Activity

N6F11 is a novel ferroptosis inducer that selectively triggers the ubiquitination degradation of GPX4 by binding to the specific structural domain of TRIM25, a ubiquitinated E3 ligase, which is expressed in tumor cells, leading to ferroptosis in cancer cells.

Chemical Information
Molecular Weight 311.19
Formula C13H8Cl2N2OS
CAS Number 851398-76-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jiao Liu, et al. Oncoimmunology. Cell type-specific induction of ferroptosis to boost antitumor immunity

[2] Jingbo Li, et al. Sci Transl Med. Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer

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  Catalog
Abmole Inhibitor Catalog




Keywords: N6F11, 2-(chloromethyl)-6-(4-chlorophenyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one supplier, Ferroptosis, inhibitors, activators

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