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Deferoxamine mesylate

Cat. No. M5558
Deferoxamine mesylate Structure
Synonym:

Desferrioxamine B mesylate; DFOM

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
25mg USD 27  USD30 In stock
50mg USD 36  USD40 In stock
100mg USD 49.5  USD55 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Deferoxamine mesylate as a chelating agent used to remove excess iron from the body. Deferoxamine is also an inhibitor of iron death that stabilizes HIF-1α expression and improves HIF-1α activity under hypoxia and hyperglycemia in vitro.

Product Citations
Customer Product Validations & Biological Datas
Source The Royal Society of Chemistry (2018 Aug). Figure 1. Deferoxamine (Abmole Bioscience)
Method Cell viability assay
Cell Lines Empty vector cells
Concentrations 0-1600 mM
Incubation Time 24, 48 and 72 h
Results Herein, we found that DFO inhibited the growth of human BEL7402 cells in a dose and time dependent manner.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 656.79
Formula C26H52N6O11S
CAS Number 138-14-7
Purity >99%
Solubility Water ≥ 60 mg/mL
Storage at -20°C
References

Effects of deferoxamine on blood-brain barrier disruption after subarachnoid hemorrhage
Yanjiang Li, et al. PLoS One. 2017 Mar 1;12(3):e0172784. PMID: 28249040.

Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing
Dominik Duscher, et al. Plast Reconstr Surg. 2017 Mar;139(3):695e-706e. PMID: 28234841.

The clinical effect of deferoxamine mesylate on edema after intracerebral hemorrhage.
Yu Y, et al. PLoS One. 2015 Apr 13;10(4):e0122371. PMID: 25875777.

Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation
Jared M Fine, et al. Neurosci Lett. 2015 Jan 1;584:362-7. PMID: 25445365.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Deferoxamine mesylate, Desferrioxamine B mesylate; DFOM supplier, Ferroptosis, inhibitors

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