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RSL3

Cat. No. M9060
RSL3 Structure
Synonym:

1S,3R-RSL3

Size Price Availability Quantity
5mg USD 108  USD120 In stock
10mg USD 189  USD210 In stock
25mg USD 409.5  USD455 In stock
50mg USD 697.5  USD775 In stock
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Quality Control
Biological Activity

RSL3 is the inhibitor of the glutathione (GSH) peroxidase 4, which can inhibit the cysteine/glutamate amino acid transporter system. RSL3 blocks GSH synthesis with an IC50 of 100 nM. RSL3, that are synthetically lethal with cell lines expressing mutant HRAS and KRAS1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 440.88
Formula C23H21ClN2O5
CAS Number 1219810-16-8
Purity 100.0%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer
Daiha Shin, et al. Free Radic Biol Med. 2018 Dec;129:454-462. PMID: 30339884.

RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death.
Dachert J, et al. Oncotarget. 2016 Sep 27;7(39):63779-63792. PMID: 27588473.

Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death.
Schott C, et al. Front Oncol. 2015 Jun 22;5:131. PMID: 26157704.

Development of small-molecule probes that selectively kill cells induced to express mutant RAS.
Weiwer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. PMID: 22297109.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: RSL3, 1S,3R-RSL3 supplier, Ferroptosis, inhibitors

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