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RSL3 is the inhibitor of the glutathione (GSH) peroxidase 4, which can inhibit the cysteine/glutamate amino acid transporter system. RSL3 is also a VDAC-independent ferroptosis activator with selectivity for tumor cells bearing oncogenic RAS. RSL3 blocks GSH synthesis with an IC50 of 100 nM. RSL3, that are synthetically lethal with cell lines expressing mutant HRAS and KRAS1.
Free Radic Biol Med. 2026 Jan; .
IER3 Promotes Non-Small Cell Lung Cancer Malignancy by Suppressing Ferroptosis via the AKT/GSK3b/NRF2 Pathway
RSL3 purchased from AbMole
Mol Cell. 2024 Sep 14.
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer
RSL3 purchased from AbMole
J Environ Sci. 2024 Feb.
Amino-modified IONPs potentiates ferroptotic cell death due to the release of Fe ion in the lysosome
RSL3 purchased from AbMole
Cell Biol Toxicol. 2024 Dec 21;41(1):14.
NMF typing and machine learning algorithm-based exploration of preeclampsia-related mechanisms on ferroptosis signature genes
RSL3 purchased from AbMole
Patent. CN116747223A 2023 Sep 15.
Patent. CN116747223A
RSL3 purchased from AbMole
Oxid Med Cell Longev. 2022 Apr 16;2022:4505513.
Nrf2-Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute-on-Chronic Liver Failure
RSL3 purchased from AbMole
Oncogene. 2021 Mar;40(9):1706-1720.
The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2
RSL3 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | HCT116, LoVo, and HT29 cells |
| Preparation method | Consequently, we used 3 μM RSL3 in HCT116, LoVo, and HT29 cells for 24 h in subsequent experiments. Interestingly, RSL3 induced growth inhibition not only in K-ras mutant HCT116 and LoVo cells but also in K-ras wild type HT29 cell. |
| Concentrations | 3 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6 mice |
| Formulation | Dissolved in 2% DMSO+30% PEG300+2%Tween 80+H2O |
| Dosages | 5 mg/kg |
| Administration | i.p. daily for 2 days |
| Molecular Weight | 440.88 |
| Formula | C23H21ClN2O5 |
| CAS Number | 1219810-16-8 |
| Solubility (25°C) | DMSO ≥ 45 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Ferroptosis Products |
|---|
| Deferiprone
Deferiprone is the only orally active iron-chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. |
| Erastin
Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, it must be prepared freshly and used immediately. |
| Ferrostatin-1
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
| Lithocholic acid
Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption, can also activate the vitamin D receptor. |
| Idebenone
Idebenone, a mitochondrial protector, has neuroprotective properties and can be used to study Alzheimer's disease, Huntington's disease, and can cross the blood-brain barrier. Idebenone (oxidized form) inhibited arachidonic acid enzyme metabolism in astrocyte homogenates (IC50=16.65 μM). Idebenone is a coenzyme Q10 analogue and antioxidant that induces apoptosis (apoptotic) in human dopaminergic neuroblastoma SHSY-5Y cells. |
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