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RSL3

Cat. No. M9060
RSL3 Structure
Synonym:

1S,3R-RSL3

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
2mg USD 55  USD55 In stock
5mg USD 85  USD85 In stock
10mg USD 150  USD150 In stock
25mg USD 300  USD300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

RSL3 is the inhibitor of the glutathione (GSH) peroxidase 4, which can inhibit the cysteine/glutamate amino acid transporter system. RSL3 is also a VDAC-independent ferroptosis activator with selectivity for tumor cells bearing oncogenic RAS. RSL3 blocks GSH synthesis with an IC50 of 100 nM. RSL3, that are synthetically lethal with cell lines expressing mutant HRAS and KRAS1.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 440.88
Formula C23H21ClN2O5
CAS Number 1219810-16-8
Purity 100.0%
Solubility DMSO ≥ 45 mg/mL
Storage -20°C, dry, sealed
References

[1] Daiha Shin, et al. Free Radic Biol Med. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

[2] Dachert J, et al. Oncotarget. RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death.

[3] Schott C, et al. Front Oncol. Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death.

[4] Weiwer M, et al. Bioorg Med Chem Lett. Development of small-molecule probes that selectively kill cells induced to express mutant RAS.

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Keywords: RSL3, 1S,3R-RSL3 supplier, Ferroptosis, inhibitors

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