All AbMole products are for research use only, cannot be used for human consumption.
RSL3 is the inhibitor of the glutathione (GSH) peroxidase 4, which can inhibit the cysteine/glutamate amino acid transporter system. RSL3 is also a VDAC-independent ferroptosis activator with selectivity for tumor cells bearing oncogenic RAS. RSL3 blocks GSH synthesis with an IC50 of 100 nM. RSL3, that are synthetically lethal with cell lines expressing mutant HRAS and KRAS1.
Mol Cell. 2024 Sep 14.
Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer
RSL3 purchased from AbMole
J Environ Sci. 2024 Feb.
Amino-modified IONPs potentiates ferroptotic cell death due to the release of Fe ion in the lysosome
RSL3 purchased from AbMole
Cell Biol Toxicol. 2024 Dec 21;41(1):14.
NMF typing and machine learning algorithm-based exploration of preeclampsia-related mechanisms on ferroptosis signature genes
RSL3 purchased from AbMole
Oxid Med Cell Longev. 2022 Apr 16;2022:4505513.
Nrf2-Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute-on-Chronic Liver Failure
RSL3 purchased from AbMole
Oncogene. 2021 Mar;40(9):1706-1720.
The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2
RSL3 purchased from AbMole
| Molecular Weight | 440.88 |
| Formula | C23H21ClN2O5 |
| CAS Number | 1219810-16-8 |
| Solubility (25°C) | DMSO ≥ 45 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Ferroptosis Products |
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| HBED
HBED is a potent iron chelator. |
| viFSP1
viFSP1 is a species-independent inhibitor of FSP1 that induces ferroptosis in FSP1-dependent cells. |
| icFSP1
icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. |
| (R)-HTS-3
(R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. |
| CuATSP
CuATSP is a potent inhibitor of ferroptosis. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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