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Piperazine Erastin is an Erastin derivative and an inducer of ferroptosis. Piperazine erastin induces an iron-dependent form of non-apoptotic cell death. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable. Piperazine erastin is affected similarly by cell death modulators as Erastin.
| Molecular Weight | 645.19 |
| Formula | C35H41ClN6O4 |
| CAS Number | 1538593-71-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Xin Chen, et al. Nat Rev Clin Oncol. Broadening horizons: the role of ferroptosis in cancer
[5] Scott J Dixon, et al. Cell. Ferroptosis: an iron-dependent form of nonapoptotic cell death
| Related Ferroptosis Products |
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| Cu-ATSM
Cu-ATSM is a copper complex that scavenges free radicals, inhibits lipid peroxidation and ferroptosis. Cu-ATSM exhibits antioxidant, anti-inflammatory and neuroprotective activities. |
| NCOA4-9a
NCOA4-9a (NCOA4-FTH1 inhibitor 9a) is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. |
| HBED
HBED is a potent iron chelator. |
| viFSP1
viFSP1 is a species-independent inhibitor of FSP1 that induces ferroptosis in FSP1-dependent cells. |
| icFSP1
icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. |
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