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Ammonium iron(III) citrate

Cat. No. M13544
Ammonium iron(III) citrate Structure
Synonym:

Ammonium ferric citrate; FAC; AFC

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1g USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis. Ammonium iron(III) citrate can enhance protein production.

Chemical Information
CAS Number 1185-57-5
Solubility (25°C) Water 33.33 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fang Wang, et al. Food Chem Toxicol. Ferric ammonium citrate (FAC)-induced inhibition of osteoblast proliferation/differentiation and its reversal by soybean-derived peptides (SDP)

[2] Wei Wu, et al. Int J Med Sci. Ammonium Ferric Citrate induced Ferroptosis in Non-Small-Cell Lung Carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity

[3] Xiaoyan Zeng, et al. Neurochem Res. Benefits of Iron Chelators in the Treatment of Parkinson's Disease

[4] Yongting Qiu, et al. Environ Technol. Effect of complex iron on the phosphorus absorption by two freshwater algae

[5] Yue Hu, et al. Spectrochim Acta A Mol Biomol Spectrosc. Fluorometric assay of iron(II) lactate hydrate and ammonium ferric citrate in food and medicine based on poly(sodium-p-styrenesulfonate)-enhanced Ag nanoclusters

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Keywords: Ammonium iron(III) citrate, Ammonium ferric citrate; FAC; AFC supplier, Ferroptosis, inhibitors, activators


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