| Cat.No. | Name | Information |
|---|---|---|
| M2698 | Ferrostatin-1 | Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
| M2679 | Erastin | Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, freshly prepared is recommended |
| M9060 | RSL3 | RSL3 is an inhibitor of the glutathione (GSH) peroxidase 4, and a ferroptosis activator, which can inhibit the cysteine/glutamate amino acid transporter system. |
| M3865 | L-Buthionine-sulfoximine | L-buthionine-sulfoximine is a cell-permeable, potent, fast-acting, irreversible g-glutamylcysteine synthetase inhibitor that consumes endogenous endogenous intracellular copper chelating agent glutathione. Sensitized cells to cell death induced by Elesclomol-copper, and the efficacy of statin inhibitors was enhanced by combination. |
| M9929 | Ammonium chloride | Ammonium chloride is mainly used in medicine, dry battery, fabric printing and dyeing, fertilizer, leather tanning, electroplating, detergent, etc. |
| M8531 | Liproxstatin-1 | Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). |
| M7504 | CIL56 (CA3) | CIL56 (CA3) is a potent and selective ferroptosis inducer, it has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. |
| M7104 | PD 146176 | PD 146176 is a selective 15-lipoxygenase inhibitor. |
| M4304 | Ergosterol | Ergosterol is a major sterol in fungi with antioxidant, antiproliferative and anti-inflammatory activities and inhibits iron death. |
| M3400 | Idebenone | Idebenone, a mitochondrial protector, has neuroprotective properties and can be used to study Alzheimer's disease, Huntington's disease, and can cross the blood-brain barrier. Idebenone (oxidized form) inhibited arachidonic acid enzyme metabolism in astrocyte homogenates (IC50=16.65 μM). Idebenone is a coenzyme Q10 analogue and antioxidant that induces apoptosis (apoptotic) in human dopaminergic neuroblastoma SHSY-5Y cells. |
| M2816 | Lithocholic acid | Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption, can also activate the vitamin D receptor. |
| M2617 | Deferiprone | Deferiprone is the only orally active iron-chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. |
| M2197 | Sulfasalazine | Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. |
| M53373 | PRDX3(103-112) SO3 modified, human | PRDX3(103-112) SO3 modified, human is a marker of ferroptosis, and can be used for liver diseases study. |
| M53372 | PRDX3(103-112), human | PRDX3(103-112), human is a marker for ferroptosis. |
| M49462 | GPX4-IN-3 | GPX4-IN-3 is a potent glutathione peroxidase 4 (GPX4) inhibitor that selectively induces ferroptosis.1 μM of GPX4-IN-3 inhibited 71.7% of GPX4 activity. |
| M45393 | YL-939 | YL-939 is a potent ferroptosis inhibitor that inhibits iron death by targeting the PHB2/ferritin/iron axis. |
| M45075 | Ferroptocide | Ferroptocide is a small molecule inhibitor of thioredoxin, as well as an inducer of ferroptosis, with antitumor activity. |
| M41341 | FSEN1 | FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. |
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