| Cat.No. | Name | Information |
|---|---|---|
| M5558 | Deferoxamine mesylate | Deferoxamine mesylate is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate acts as a chelating agent used to remove excess iron from the body. |
| M2698 | Ferrostatin-1 | Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. |
| M2679 | Erastin | Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. *The compound is unstable in solutions, freshly prepared is recommended |
| M9060 | RSL3 | RSL3 is an inhibitor of the glutathione (GSH) peroxidase 4, and a ferroptosis activator, which can inhibit the cysteine/glutamate amino acid transporter system. |
| M3865 | L-Buthionine-sulfoximine | L-buthionine-sulfoximine is a cell-permeable, potent, fast-acting, irreversible g-glutamylcysteine synthetase inhibitor that consumes endogenous endogenous intracellular copper chelating agent glutathione. Sensitized cells to cell death induced by Elesclomol-copper, and the efficacy of statin inhibitors was enhanced by combination. |
| M9929 | Ammonium chloride | Ammonium chloride is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.Ammonium chloride is also a lysosome inhibitor. |
| M2617 | Deferiprone | Deferiprone is the only orally active iron-chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. |
| M10587 | ML162 | ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces iron death and has shown cytotoxic effects against melanoma, lung adenocarcinoma, fibrosarcoma, and pancreatic cancer cell lines. |
| M10587 | ML162 | ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces iron death and has shown cytotoxic effects against melanoma, lung adenocarcinoma, fibrosarcoma, and pancreatic cancer cell lines. |
| M10586 | JKE-1674 | JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1. |
| M10244 | Imidazole ketone erastin | Imidazole Ketone Erastin (IKE) is an inducer for ferroptosis iron death. It is also a potent, selective, and metabolically stable system XC -- inhibitor. IKE is more water-soluble than Erastin. Inducing iron death in diffuse large B-cell lymphoma cells (e.g. Sudhl-5/6/16). |
| M9404 | UAMC-3203 hydrochloride | UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor, with an IC50 of 12 nM. |
| M8531 | Liproxstatin-1 | Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). |
| M7734 | CP-24879 hydrochloride | CP-24879 hydrochloride is a potent, selective and combined delta5D/delta6D desaturase inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. |
| M7504 | CIL56 (CA3) | CIL56 (CA3) is a potent and selective ferroptosis inducer, it has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. |
| M7104 | PD 146176 | PD 146176 is a selective 15-lipoxygenase inhibitor. |
| M4304 | Ergosterol | Ergosterol is a major sterol in fungi with antioxidant, antiproliferative and anti-inflammatory activities and inhibits iron death. |
| M3400 | Idebenone | Idebenone, a mitochondrial protector, has neuroprotective properties and can be used to study Alzheimer's disease, Huntington's disease, and can cross the blood-brain barrier. Idebenone (oxidized form) inhibited arachidonic acid enzyme metabolism in astrocyte homogenates (IC50=16.65 μM). Idebenone is a coenzyme Q10 analogue and antioxidant that induces apoptosis (apoptotic) in human dopaminergic neuroblastoma SHSY-5Y cells. |
| M2816 | Lithocholic acid | Lithocholic acid is a bile acid that acts as a detergent to solubilize fats for absorption, can also activate the vitamin D receptor. |
| M2617 | Deferiprone | Deferiprone is the only orally active iron-chelating agent with an affinity for ferric ion (iron III)，binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. |
| M2197 | Sulfasalazine | Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. |
| M55891 | viFSP1 | viFSP1 is a species-independent inhibitor of FSP1 that induces ferroptosis in FSP1-dependent cells. |
| M55890 | icFSP1 | icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. |
| M55889 | (R)-HTS-3 | (R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. |
| M55223 | CuATSP | CuATSP is a potent inhibitor of ferroptosis. |
| M55222 | YL-939 | YL-939 is a novel non-classical and specific ferroptosis inhibitor, targets and binds directly to the prohibitin 2 (PHB2) protein with Kd of 3.43 uM in SPR assays. |
| M53373 | PRDX3(103-112) SO3 modified, human | PRDX3(103-112) SO3 modified, human is a marker of ferroptosis, and can be used for liver diseases study. |
| M53372 | PRDX3(103-112), human | PRDX3(103-112), human is a marker for ferroptosis. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
