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UAMC-3203 hydrochloride

Cat. No. M9404
UAMC-3203 hydrochloride Structure

UAMC-3203 HCl

Size Price Availability Quantity
5mg USD 79.2  USD88 In stock
10mg USD 129.6  USD144 In stock
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Quality Control
Biological Activity

UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor, with an IC50 of 12 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 508.12
Formula C25H38ClN5O2S
CAS Number 2271358-65-5
Purity 99.87%
Solubility DMSO ≥ 25 mg/mL
Storage 4°C, protect from light, dry, sealed

Discovery of Novel, D rug-Like Ferroptosis Inhibitors with in Vivo Efficacy.
Devisscher L, et al. J Med Chem. 2018 Nov 21;61(22):10126-10140. PMID: 30354101.

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Keywords: UAMC-3203 hydrochloride, UAMC-3203 HCl supplier, Ferroptosis, inhibitors

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