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UAMC-3203 hydrochloride

Cat. No. M9404
UAMC-3203 hydrochloride Structure
Synonym:

UAMC-3203 HCl

Size Price Availability Quantity
5mg USD 88  USD88 In stock
10mg USD 144  USD144 In stock
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Quality Control & Documentation
Biological Activity

UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor, with an IC50 of 12 nM.

Chemical Information
Molecular Weight 508.12
Formula C25H38ClN5O2S
CAS Number 2271358-65-5
Solubility (25°C) DMSO ≥ 25 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Devisscher L, et al. J Med Chem. Discovery of Novel, D rug-Like Ferroptosis Inhibitors with in Vivo Efficacy.

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Keywords: UAMC-3203 hydrochloride, UAMC-3203 HCl supplier, Ferroptosis, inhibitors, activators

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