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JKE-1674

Cat. No. M10586

All AbMole products are for research use only, cannot be used for human consumption.

JKE-1674 Structure
Synonym:

JKE1674

Size Price Availability Quantity
1mg USD 48  USD48 In stock
5mg USD 118  USD118 In stock
10mg USD 189  USD189 In stock
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Quality Control & Documentation
Biological Activity

JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1. JKE-1674 forms a nitrile-oxide electrophile in cells. JKE-1674 dehydration yields a nitrile-oxide electrophile that binds GPX4. JKE-1674 exhibits far greater stability than chloroacetamide inhibitors.

Chemical Information
Molecular Weight 451.30
Formula C20H20Cl2N4O4
CAS Number 2421119-60-8
Solubility (25°C) DMSO 60 mg/mL
Storage 2-8°C, protect from light, sealed
References

[1] John K Eaton, et al. Nat Chem Biol. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

[2] Stefan G Kathman, et al. Nat Chem Biol. A masked zinger to block GPX4

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  Catalog
Abmole Inhibitor Catalog




Keywords: JKE-1674, JKE1674 supplier, Ferroptosis, inhibitors, activators

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