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JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1. JKE-1674 forms a nitrile-oxide electrophile in cells. JKE-1674 dehydration yields a nitrile-oxide electrophile that binds GPX4. JKE-1674 exhibits far greater stability than chloroacetamide inhibitors.
| Molecular Weight | 451.30 |
| Formula | C20H20Cl2N4O4 |
| CAS Number | 2421119-60-8 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
[2] Stefan G Kathman, et al. Nat Chem Biol. A masked zinger to block GPX4
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