Certificate of Analysis
| Product Name: | JKE-1674 |
| Catalog Number: | M10586 |
| CAS Number: | 2421119-60-8 |
Physical and Chemical Properties
| Formula: | C20H20Cl2N4O4 |
| Molecular Weight: | 451.30 |
| Solubility: | DMSO 60 mg/mL |
| Storage: | 2-8°C, protect from light, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |