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FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation. FINO2 (10 µM; 24 h) induce ferroptosis and shows iron dependence of lipid peroxidation in HT-1080 cells.
| Molecular Weight | 256.39 |
| Formula | C15H28O3 |
| CAS Number | 869298-31-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage | 4°C, protect from light |
| Related Ferroptosis Products |
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| Cu-ATSM
Cu-ATSM is a copper complex that scavenges free radicals, inhibits lipid peroxidation and ferroptosis. Cu-ATSM exhibits antioxidant, anti-inflammatory and neuroprotective activities. |
| NCOA4-9a
NCOA4-9a (NCOA4-FTH1 inhibitor 9a) is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. |
| HBED
HBED is a potent iron chelator. |
| viFSP1
viFSP1 is a species-independent inhibitor of FSP1 that induces ferroptosis in FSP1-dependent cells. |
| icFSP1
icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. |
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