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PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo.
| Molecular Weight | 237.32 |
| Formula | C15H11NS |
| CAS Number | 4079-26-9 |
| Solubility (25°C) | DMSO: 23 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Ferroptosis Products |
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Cu-ATSM is a copper complex that scavenges free radicals, inhibits lipid peroxidation and ferroptosis. Cu-ATSM exhibits antioxidant, anti-inflammatory and neuroprotective activities. |
| NCOA4-9a
NCOA4-9a (NCOA4-FTH1 inhibitor 9a) is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. |
| HBED
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| viFSP1
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icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. |
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Products are for research use only. Not for human use. We do not sell to patients.
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