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UAMC-3203

Cat. No. M10626
UAMC-3203 Structure
Synonym:

UAMC3203

Size Price Availability Quantity
5mg USD 88  USD88 In stock
10mg USD 144  USD144 In stock
25mg USD 232  USD232 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

UAMC-3203 is an improved ferroptosis inhibitor, with an IC50 value of 10 nM in IMR-32 neuroblastoma cells. In vivo, UAMC-3203 significantly lowers the plasma levels of lactate dehydrogenase (LDH) in mice. It is rapidly removed from the bloodstream and redistributed into various tissues, as can be expected for lipophilic basic compounds.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 471.66
Formula C25H37N5O2S
CAS Number 2271358-64-4
Purity >98.5%
Solubility DMSO ≥ 60 mg/mL
Storage 2-8°C, protect from light, sealed
References

[1] Lars Devisscher, et al. J Med Chem . Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy

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Keywords: UAMC-3203, UAMC3203 supplier, Ferroptosis, inhibitors

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