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SRS16-86

Cat. No. M11044
SRS16-86  Structure
Size Price Availability Quantity
1mg USD 35  USD35 In stock
5mg USD 80  USD80 In stock
10mg USD 125  USD125 In stock
25mg USD 240  USD240 In stock
50mg USD 370  USD370 In stock
100mg USD 580  USD580 In stock
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Quality Control & Documentation
Biological Activity

SRS16-86 is a potent inhibitor of ferroptosis. SRS16-86 is more metabolically and plasma-stable in vivo than Ferrostatin-1. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) studies.

Chemical Information
Molecular Weight 432.56
Formula C26H32N4O2
CAS Number 1793052-96-6
Solubility (25°C) DMSO ≥ 1 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: SRS16-86 supplier, Ferroptosis, inhibitors, activators


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