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CIL56 (CA3) is a potent and selective ferroptosis inducer, it has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties.
In vitro: CIL56 (CA3) strongly inhibits esophageal adenocarcinoma cell growth in vitro. CIL56 (CA3) can effectively suppress tumor cell proliferation, induce apoptosis, reduce tumor sphere formation, and the population of ALDH1+ cells. CIL56 (CA3) specially inhibits Tead/YAP1 transcriptional activity but shows no inhibitory activity on other transcriptional factors-Super-TOP/Wnt, CBF1/Notch, and AP-1 after cotransfection of their respective individual promoter luciferases in 293T cells. CIL56 (CA3) preferentially inhibits CSC properties enriched in radiation-resistant esophageal adenocarcinoma cells.
In vivo: CIL56 (CA3) exerts strong antitumor activity in xenograft model with no apparent toxicity.
| Cell Experiment | |
|---|---|
| Cell lines | SKGT-4 and JHESO cells |
| Preparation method | SKGT-4 and JHESO cells are seeded onto 6-well plates (1 × 105/well) in DMEM and cultured for 24 hours to allow for cell attachment. The cells are then treated with 0.1% DMSO (control) or CA3 at different doses as indicated for 48 hours. Next, the cells are harvested, fixed with methanol, washed, treated with RNase A, and stained for DNA with propidium iodide, and their DNA histograms and cell-cycle phase distributions are analyzed using flow cytometry. |
| Concentrations | 0.5 and 1 μmol/L |
| Incubation time | 48 hours |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 489.61 |
| Formula | C23H27N3O5S2 |
| CAS Number | 300802-28-2 |
| Solubility (25°C) | DMSO 40 mg/mL (May need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Lu L, et al. Neuron. Topography of Place Maps along the CA3-to-CA2 Axis of the Hippocampus.
| Related Ferroptosis Products |
|---|
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| icFSP1
icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. |
| (R)-HTS-3
(R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. |
| CuATSP
CuATSP is a potent inhibitor of ferroptosis. |
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