Dicyclol is an anti-hepatitis compound used in studies of chronic hepatitis B and possibly hepatitis C in China. The compound appears to prevent liver damage in animals. Recently, it has been reported that dicyclol induces the expression of HSP27 and HSP70 in liver, thereby inhibiting the transcription factor NF-? B - mediated apoptosis and necrosis of liver tissue. These results suggest that dicyclol may induce the expression of HSP27 and HSP70 in liver by activating the transcription of HSPs gene.
| Molecular Weight | 390.34 |
| Formula | C19H18O9 |
| CAS Number | 118159-48-1 |
| Solubility (25°C) | DMSO: ≥10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Xiao-Lin Li, et al. Bicyclol Alleviates Atherosclerosis by Manipulating Gut Microbiota
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