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JSH-23

Cat. No. M2786

All AbMole products are for research use only, cannot be used for human consumption.

JSH-23 Structure
Size Price Availability Quantity
2mg USD 65  USD65 In stock
5mg USD 113  USD113 In stock
10mg USD 170  USD170 In stock
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Biological Activity

Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα.

Product Citations
Chemical Information
Molecular Weight 240.34
Formula C16H20N2
CAS Number 749886-87-1
Solubility (25°C) DMSO 28 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Liangwei Mei, et al. The Novel Antioxidant Compound JSH-23 Prevents Osteolysis by Scavenging ROS During Both Osteoclastogenesis and Osteoblastogenesis

[2] Xueliang Chen, et al. NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling

[3] Xuan Peng, et al. ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury

[4] Qi Wang, et al. JSH-23 prevents depressive-like behaviors in mice subjected to chronic mild stress: Effects on inflammation and antioxidant defense in the hippocampus

[5] A Kumar, et al. JSH-23 targets nuclear factor-kappa B and reverses various deficits in experimental diabetic neuropathy: effect on neuroinflammation and antioxidant defence

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Keywords: JSH-23 supplier, NF-κB, inhibitors, activators

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