Cat.No. | Name | Information |
---|---|---|
M7490 | Withaferin A | Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects. |
M5580 | Dimethyl Fumarate | Dimethyl Fumarate (DMF) is an orally active Monomethyl fumarate (MMF) precursor compound that is also an Nrf2 pathway activator and inhibits NF-κB. In addition, Dimethyl Fumarate also inhibits GAPDH and can be used in studies related to multiple sclerosis (MS) and psoriasis. |
M4940 | SC75741 | SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. |
M4005 | Pyrrolidinedithiocarbamate ammonium (PDTC) | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective nuclear factor-κB (NF-κB) inhibitor. |
M3985 | Triptolide | Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. |
M2786 | JSH-23 | Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
M2298 | QNZ | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. |
M44850 | Ergolide | Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. |
M44092 | Chiisanoside | Chiisanoside is a triterpenoid natural product derived from Eleutherococcus sessiliflorus, which inhibits the NF-κB and Nrf2/HO-1 pathways.Chiisanoside possesses neuroprotective activity, anti-inflammatory, and antioxidant activity. In addition, Chiisanoside was effective in mitigating reactive oxygen species generation and apoptosis in SH-SY5Y cells in the 6-hydroxydopamine (6-OHDA) model, thereby attenuating DA neuronal degeneration and shortening of lifespan. |
M40800 | Neocryptotanshinone | Neocryptotanshinone, a fat-soluble active compound derived from Salvia miltiorrhiza, can show anti-inflammatory activity by inhibiting the NF-κB and iNOS signaling pathways and can enhance lysosomal fusion and hydrolysis, limiting oxidative stress and apoptosis in vivo and in vitro. |
M40630 | NF-κΒ activator 1 | NF-κΒ activator 1 is a potent NF-κΒ activator with an EC50 of 0.9 μM and induces superoxide dismutase (SOD)2 mRNA expression. |
M31397 | Myrcene | Myrcene is a monoterpene compound found in many plants that inhibits both MAP kinase and NF-κB pathways, thereby suppressing colonic inflammation. |
M29555 | NF-κΒ activator 2 | NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS). |
M25465 | B022 | B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 4.2 nM and IC50 of 15.1 nM. B022 protects liver from toxin-induced inflammation, oxidative stress and injury. |
M25407 | SN52 | SN52 is a novel potent, competitive, and cell-permeable inhibitor of nuclear factor-kappaB (NF-κB). SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. |
M21470 | CDDO-dhTFEA | CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound that effectively activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. |
M21403 | CORM-3 | CORM-3 is a carbon monoxide-releasing molecule that attenuates nuclear ectopic NF-κB p65, reduces ROS production, and increases intracellular glutathione and superoxide dismutase levels.CORM-3 reduces the activation of NLRP3 inflammatory vesicles. |
M19347 | Nimbolide | Nimbolide induces apoptosis through inactivation of NF-κB. Nimbolide inhibits CDK4/CDK6 kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways. |
M19176 | Sappanone A | Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. |
M18255 | Hesperidin methylchalcone | Hesperidin methylchalcone |
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