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NF-κB Nuclear factor kappa-light-chain-enhancer of activated B cells

Inhibitors

Cat.No.  Name Information
M4005 Pyrrolidinedithiocarbamate ammonium (PDTC) Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective nuclear factor-κB (NF-κB) inhibitor.
M5580 Dimethyl Fumarate Dimethyl fumarate(DMF) is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression.
M4940 SC75741 SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins.
M14612 Tomatidine hydrochloride Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans.
M14611 Tomatidine Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans.
M14610 Stachydrine hydrochloride Stachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities.
M14609 Stachydrine Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.
M14608 Sinomenine Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation. Sinomenine also is an activator of μ-opioid receptor.
M14607 Rocaglamide Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases.
M14606 Quinoclamine Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity.
M14605 Micheliolide Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).
M14604 Isoliquiritin apioside Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB.
M14603 Indole-3-carbinol Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).
M14602 FW1256 FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H2S) donor.
M14601 Erdosteine Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects.
M14600 DCZ0415 DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity. DCZ0415 induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients.
M14599 Asatone Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways.
M14598 Inulicin Inulicin (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK.
M14597 14-Deoxy-11,12-didehydroandrographolide 14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide. 14-Deoxy-11,12-didehydroandrographolide inhibits NF-κB activation.
M13449 Ac2-26 TFA Ac2-26 TFA, an active N-terminal peptide of adiponectin A1 (AnxA1), alleviates acute lung injury induced by ischemia-reperfusion. Ac2-26 also decreased AnxA1 protein expression and inhibited the activation of NF-κB and MAPK pathways in damaged lung tissue. Sequence Shortening: Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-GIn-Ala-Trp-Phe-lle-Glu-Asn-Glu-Glu-GIn-Glu-Tyr-Val-GIn-Thr-Val-Lys
M11454 (-)-DHMEQ (-) - DHMEQ (Dehydroxymethylepoxyquinomicin) is an effective and selective and irreversible nf-kappa B inhibitors, covalent binding and cysteine residues. (-)-DHMEQ inhibited nuclear NF-κB translocation and showed anti-inflammatory and anticancer activity.
M10982 α-Lipoic Acid α-Lipoic Acid is an antioxidant that is an important cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum stress (ER)-mediated apoptosis of liver cancer cells.
M10653 Dehydroevodiamine Dehydroevodiamine has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.



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