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Chiisanoside

Cat. No. M44092

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Chiisanoside Structure
Size Price Availability Quantity
5mg USD 780  USD780 In stock
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Quality Control & Documentation
Biological Activity

Chiisanoside is a triterpenoid natural product derived from Eleutherococcus sessiliflorus, which inhibits the NF-κB and Nrf2/HO-1 pathways.Chiisanoside possesses neuroprotective activity, anti-inflammatory, and antioxidant activity. In addition, Chiisanoside was effective in mitigating reactive oxygen species generation and apoptosis in SH-SY5Y cells in the 6-hydroxydopamine (6-OHDA) model, thereby attenuating DA neuronal degeneration and shortening of lifespan. 

Chemical Information
Molecular Weight 955.1
Formula C48H74O19
CAS Number 89354-01-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yu-Ling Hsu, et al. Antioxidants (Basel). Chiisanoside Mediates the Parkin/ZNF746/PGC-1α Axis by Downregulating MiR-181a to Improve Mitochondrial Biogenesis in 6-OHDA-Caused Neurotoxicity Models In Vitro and In Vivo: Suggestions for Prevention of Parkinson's Disease

[2] Xingbo Bian, et al. J Sci Food Agric. Hepatoprotective effect of chiisanoside from Acanthopanax sessiliflorus against LPS/D-GalN-induced acute liver injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways

[3] Xingbo Bian, et al. Nat Prod Res. Hepatoprotective effect of chiisanoside against acetaminophen-induced acute liver injury in mice

[4] Xingbo Bian, et al. Int Immunopharmacol. Study on antidepressant activity of chiisanoside in mice

[5] Kazuma Yoshizumi, et al. Biosci Biotechnol Biochem. Chiisanoside is not absorbed but inhibits oil absorption in the small intestine of rodents

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Keywords: Chiisanoside supplier, NF-κB, inhibitors, activators

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