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PTD-p65-P1 Peptide TFA

Cat. No. M55225
PTD-p65-P1 Peptide TFA Structure
Size Price Availability Quantity
5mg USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis. PTD-p65-P1 Peptide TFA (150 μM; 12-24 h) inhibits the SP-53 cells proliferation.

Sequence: DRQIKIWFQNRRMKWKKQLRRPSDRELSE

Chemical Information
Molecular Weight 3943.52
Formula C170H276F3N57O46S
Solubility (25°C) Water 100 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: PTD-p65-P1 Peptide TFA supplier, NF-κB, inhibitors, activators


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