| Cat.No. | Name | Information |
|---|---|---|
| M4005 | Pyrrolidinedithiocarbamate ammonium (PDTC) | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective nuclear factor-κB (NF-κB) inhibitor. |
| M5580 | Dimethyl Fumarate | Dimethyl Fumarate (DMF) is an orally active Monomethyl fumarate (MMF) precursor compound that is also an Nrf2 pathway activator and inhibits NF-κB. In addition, Dimethyl Fumarate also inhibits GAPDH and can be used in studies related to multiple sclerosis (MS) and psoriasis. |
| M4940 | SC75741 | SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. |
| M3985 | Triptolide | Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. |
| M2298 | QNZ | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. |
| M7490 | Withaferin A | Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects. |
| M2786 | JSH-23 | Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| M6179 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. |
| M19371 | Handelin | Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production. |
| M19335 | Valencene | Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene is used to flavor foods and drinks. |
| M19263 | Adenanthin | Adenanthin is an inhibitor of thiol-dependent antioxidant enzymes, targeting to Prx 1 and Prx 2. Adenanthin inhibits NF-κB signaling and lipogenesis and the development of obesity by regulating ROS. |
| M19150 | Lucyoside B | Lucyoside B inhibits the production of inflammatory mediators via both NF-κB and activator protein-1 pathways in activated macrophages. |
| M18295 | Rubiadin 1-methyl ether | Rubiadin 1-methyl ether |
| M14610 | Stachydrine hydrochloride | Stachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities. |
| M14606 | Quinoclamine | Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity. |
| M14605 | Micheliolide | Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs). |
| M14604 | Isoliquiritin apioside | Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. |
| M14602 | FW1256 | FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H2S) donor. |
| M11454 | (-)-DHMEQ | (-) - DHMEQ (Dehydroxymethylepoxyquinomicin) is an effective and selective and irreversible nf-kappa B inhibitors, covalent binding and cysteine residues. (-)-DHMEQ inhibited nuclear NF-κB translocation and showed anti-inflammatory and anticancer activity. |
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