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NF-κB Nuclear factor kappa-light-chain-enhancer of activated B cells

Cat.No.  Name Information
M4005 Pyrrolidinedithiocarbamate ammonium (PDTC) Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective nuclear factor-κB (NF-κB) inhibitor.
M5580 Dimethyl Fumarate Dimethyl Fumarate (DMF) is an orally active Monomethyl fumarate (MMF) precursor compound that is also an Nrf2 pathway activator and inhibits NF-κB. In addition, Dimethyl Fumarate also inhibits GAPDH and can be used in studies related to multiple sclerosis (MS) and psoriasis.
M4940 SC75741 SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins.
M3985 Triptolide Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities.
M2298 QNZ QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM.
M7490 Withaferin A Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects.
M2786 JSH-23 Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα.
M6179 Diethylmaleate Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.
M4523 Specnuezhenide Specnuezhenide ((8E)-Nuezhenide) was separated from the fruit of the ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) inhibited IL-1β -induced chondrocyte inflammation by inhibiting NF-κB and WNT /β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) showed anti-inflammatory effects in rat models of osteoarthritis (OA).
M4516 Sinomenine-Hydrochloride Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid derived from Sinomenium Acutum, is a blocker of NF-κB activation. Sinomenine is also a μ-opioid receptor activator.
M4504 Sanggenone-C Sanggenon C is a flavanone diels-Alder adduct compound isolated from the root bark of the genus Morus Cathayana.
M4481 Mangiferin Mangiferin is an Nrf2 activator. Mangiferin inhibits nuclear translocation of NF-κB subunit P65 and P50. Mangiferin has antioxidant, anti-diabetic, anti-hyperuricemia, antiviral, anticancer and anti-inflammatory activities.
M4455 5-O-Methylvisammioside 5-O-methylvisammioside isa natural compound isolated from parsnip.
M4412 Picroside-II Picroside II lutein II is a iridoid compound extracted from Lutein, which has anti-inflammatory and anti-apoptotic effects.
M4407 Demethyleneberberine Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates colitis and inhibits inflammation in mice by inhibiting the NF-κB pathway and regulating Th cell balance. Demethyleneberberine can be used as an AMPK activator in the study of non-alcoholic fatty liver disease (NAFLD).
M4353 Myrislignan Myrislignan is a lignan isolated from Myristica Fragrans Houtt with anti-inflammatory activity. Myrislignan mitigated LPS-induced inflammation in mouse macrophages by inhibiting the activation of the NF-KB signaling pathway.
M4351 Dehydrodiisoeugenol Dehydrodiisoeugenol was isolated from Myristica Fragrans Houtt with anti-inflammatory and antibacterial effects. Dehydrodiisoeugenol inhibited NF-κB activation and cycde-2 gene expression in LPS-stimulated mouse macrophages.
M4345 Barlerin Barlerin (8-O-acetyl Shanzhiside methyl ester) is a cyclosporin glucoside isolated from folk medicinal plants in Xizang, China. Barlerin (8-O-acetyl Shanzhiside methyl ester) inhibited NF-κB activity.
M4279 Isorhychophylline Rhyncholphylline is a kind of alkaloid compound isolated from Uncaria. It has high biological activity and has been widely used in anti-inflammatory and neuroprotective studies.
M4278 Rhynchophylline Rhyncholphylline is a kind of alkaloid compound isolated from Uncaria. It has high biological activity and has been widely used in anti-inflammatory and neuroprotective studies.
M4276 Tyrosol Tyrosol is a derivative of phenyl ethanol. Tyrosol attenuates pro-inflammatory cytokines from astrocytes and decreases NF-κB activation. It has antioxidant and anti-inflammatory effects.
M4249 Schisandrol B Schisandrol B is a major active constituent of Schisandra sphenanthera with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities.
M4230 Armepavine Armepavine is an active compound from Nelumbo Nucifera, which not only has anti-inflammatory effect on human peripheral blood monocytes, but also has immunosuppressive effect on T lymphocytes and lupus nephritis mice. Armepavine inhibits TNF-α - induced MAPK and NF-κB signaling cascade.
M4228 Neferine Neferine is a bisbenzylisoquinoline alkaloid extracted from Plumbago officinalis, which reduces lipid accumulation and promotes β-oxidation through activation of the AMPK pathway in hepatocytes, and possesses anti-inflammatory, antioxidant, and antipulmonary fibrosis activities. In addition, Neferine potently inhibits NF-κB activation.The affinity Kd value of Neferine for ABCB1 is 0.659 μM.It can be used in studies related to non-alcoholic steatohepatitis (NASH).
M4187 Senegenin Tenuigenin is the main active ingredient isolated from the roots of Polygala tenuifolia. Tenuigenin prevents staphylococcus aureus-induced pneumonia by inhibiting NF-κB activation.
M4179 Neochlorogenic-acid Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid can inhibit the production of TNF-α and IL-1β. Neochlorogenic acid inhibited the expression of iNOS and COX-2 proteins. Neochlorogenic acid also inhibited the activation of phosphorylated NF-κB P65 and P38 MAPK.
M4126 Zingerone Zingerone (Vanillylacetone) is a non-toxic methoxyphenol obtained from ginger. It has anti-inflammatory, anti-diabetes, anti-lipid allergy, anti-diarrhea, anti-spasticity and anti-tumor activities. Zingerone reduces oxidative stress and inflammation and down-regulates NF-κB signaling. Zingerone acts as an anti-mitotic agent and inhibits the growth of neuroblastoma.
M4092 Ginsenoside-Rk1 Ginsenoside Rk1 is a high-temperature processed extract of ginseng. Ginsenoside Rk1 has anti-inflammatory effects and inhibits Jak2/Stat3 signaling pathway and NF-κB activation.




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